Background Pulmonary fibrosis is of critical importance in childhood interstitial lung disease (chILD), yet fibrosis prevalence, impact on the clinical progression, and survival have not been systematically evaluated. Methods Data were extracted from the chILD-EU register, a European prospective multicenter cohort study with centralized peer-review on patient inclusion and systematic scoring of computed tomography (CT) […]

Background: The high cost and widespread use of glucagon-like peptide 1 receptor agonists (GLP-1RAs) are a concern for healthcare budgets. Whether GLP-1RA use reduces other health care spending is unclear. Methods: We conducted a cohort study using insurance claims data for United States adults aged 18-64 from 2016-2024, matching GLP-1RA treated members with untreated members […]

Aim: Species and ecosystem processes offer essential benefits to people, known as Nature’s Contributions to People (NCP). However, we still lack a comprehensive understanding of NCP provided by terrestrial vertebrates on a large scale, and of the threats they face. To bridge this gap, we built a comprehensive dataset that documents the NCP provided by […]

Advances in artificial intelligence (AI) have transformed the field of protein structure, notably with the accuracy level reached by AlphaFold in the prediction of monomeric and multimeric protein structures. However, while cloud implementations have broadened access to these methods, there is still a lack of non-AI tools to systematically interpret and analyze the resulting data, […]

Atopic dermatitis is an allergic skin disease associated with a profound reorganization of the epidermal lipidome. The effect of the altered lipidome on the skin resident immune cells that drive disease is unclear. Previous reports identified Fatty acid binding protein 5 (FABP5) as a biomarker for atopic dermatitis, yet how FABP5 might contribute to disease […]

Leigh syndrome (LS) is a devastating mitochondrial disease (MD) for which there is no treatment. Together with Leigh-like syndrome (LLS), LS constitutes part of the Leigh syndrome spectrum (LSS) disorders, which are the most frequent manifestation of a primary mitochondrial disease (MD) in children. Ndufs4-/- mice are a widely used animal model to study LS […]

While neural oscillations are conventionally assessed via their frequency, power and phase, developing literature suggests that their shape also provides neurophysiological and functional information. However, the extent to which the shape of oscillations recorded non-invasively in humans index specific brain processes remains unclear. This study implemented a pharmaco-EEG approach to begin addressing this limitation. In […]

Cerebral malaria (CM) is a complex multi-systemic disorder defined by diffuse encephalopathy and acute neurological manifestations, including altered consciousness, deep coma, and seizures preceding death. During infection, astrocytes undergo profound morphological and molecular changes, adopting a reactive state that alters their normal functions. This reactivity involves a shift from a neuroprotective (A2) to a neurotoxic […]

T cell receptor (TCR) signaling is critically dependent on the Src-family kinase Lck, whose activation is tightly regulated both spatially and conformationally during antigen recognition. Here, we employ a third-generation FRET-based biosensor (TqLck-V2.3) to visualize Lck conformational dynamics in live T cells with high spatial resolution. Upon TCR engagement, we observe a paradoxical increase in […]

Avoiding actions with negative consequences is fundamental to adaptive behaviour, yet individuals differ drastically in their tendencies to avoid to punishment. Using a conditioned punishment task in male and female rats, we replicate findings of a bimodal distribution of punishment avoidance, and identify four distinct behavioural phenotypes (Sensitive, Hypersensitive, Insensitive, Generalised) that differed in their […]