Skeletal muscle is critical to whole-body functionality and homeostasis. The mammalian /mechanistic target of rapamycin complex 1 (mTORC1) is a nutrient and growth/factor sensitive positive regulator of skeletal muscle mass. Amongst other substrates, mTORC1 phosphorylates the ribosomal protein S6 kinase (S6K1). Activated S6K1 acts through multiple effectors, including programmed cell death 4 (PDCD4), to activate […]

Hallmark gene mutations shape cancer cell vulnerabilities and inform drug discovery. A systematic map of hallmark gene mutation-defined cancer dependencies and therapeutic responses is essential to uncover novel targets and refine therapeutic strategies. Here, we present the first pan-cancer blueprint of hallmark vulnerabilities, systematically linking hallmark gene mutation markers to cancer cell dependencies and drug […]

Background Female Genital Schistosomiasis (FGS) is an critical complication of schistosome infection, especially in schistosomiasis-endemic areas. It is a neglected disease and remains under-recognized in many areas. The prevalence of visual FGS in the endemic areas of Southern Malawi is 26.9%. This is higher in other African countries including Zambia and Tanzania and nosuch studies […]

The discovery of increased vigor and yield in hybrid corn compared to inbred lines dates to the early 20th century. If hybrid vigor could be maintained across generations, it would revolutionize agriculture. A potential method to achieve this goal is asexual reproduction through seed (apomixis). We searched for mutants mimicking components of apomixis and here, […]

Health monitoring of laboratory rodents is essential for ensuring animal welfare, meeting regulatory requirements for zoonosis control, and maintaining the integrity and reproducibility of scientific studies. Routine serological screening, conducted in accordance with FELASA guidelines, plays a critical role in the detection of infectious agents. While conventional serological assays typically target individual pathogens, existing multiplex […]

Pancreatic cancer ranks fourth among cancer-related deaths. Despite decades of research, the cure rate of disease remains disappointingly low. This dismal prognosis is due to late detection and to resistance of tumors to all known systemic therapies. Here, we build upon our previous findings that highlighted the selective uptake of tumor-associated macrophage-derived exosomes by cancer […]

Cold tumors like pancreatic cancer suffer from poor immune infiltration, limiting effective anti-tumor responses. The chemokine CXCL9 promotes immune cell recruitment, but the signaling mechanisms regulating its expression in tumor cells remain poorly understood and underexplored as targets for modulation. We present a framework that integrates active learning with mechanistic logic-ODE models to guide perturbation […]

Maintaining internal water balance, including ionic and osmotic balance, is critical for animal development and survival. In insects, internal water balance is regulated through the Malpighian tubules and the hindgut, which transport water and ions across their epithelia under the regulation of multiple peptide hormones. One of these, ion transport peptide (ITP), a member of […]

Understanding the extent to which genetic correlations change in response to environmental factors, such as temperature, is a poorly explored question, despite the importance of understanding how different processes will change with climate warming. Despite correlations between thermal performance traits having been reported in the literature for a few taxa and performance tasks, such as […]

The Martini coarse-grained (CG) force field enables efficient simulations of biomolecular systems but cannot reliably maintain folded protein structures. To stabilize proteins during simulation, Martini is typically combined with structure-based force fields such as elastic network models (ENMs) or G[o] models. While these approaches preserve global folds and capture protein flexibility, their ability to reproduce […]