arXiv:2407.17489v2 Announce Type: replace-cross Abstract: AI is not only a neutral tool in team settings; it actively reshapes the social and cognitive fabric of collaboration. We advance a unified framework of alignment in distributed cognition in human-AI teams — a process through which linguistic, cognitive, and social coordination emerge as human and AI agents co-construct […]
Retrieval Augmented Generation-Enhanced Distributed LLM Agents for Generalizable Traffic Signal Control with Emergency Vehicles
arXiv:2510.26242v1 Announce Type: new Abstract: With increasing urban traffic complexity, Traffic Signal Control (TSC) is essential for optimizing traffic flow and improving road safety. Large Language Models (LLMs) emerge as promising approaches for TSC. However, they are prone to hallucinations in emergencies, leading to unreliable decisions that may cause substantial delays for emergency vehicles. Moreover, […]
Gilead sees cell therapy sales decline in Q3
Gilead Sciences said that its cell therapy revenue dropped 11% in the third quarter, compared with a year ago, citing lower demand for its two CAR-T cell therapies, Yescarta and Tecartus. The light quarter, with …
Fatigue Symptoms Influence Effort-Based Decision-Making in Major Depressive Disorder
Background: Fatigue is a central symptom of major depressive disorder (MDD). Research in healthy individuals has shown that heightened feelings of fatigue are associated with a reduced willingness to exert effort. However, it remains unclear how fatigue affects effort-based decision-making in individuals with MDD. In this study, we explore how cognitive effort is traded for […]
An ELISA for discovering protein-protein interaction inhibitors: blocking lysinoalanine crosslinking between subunits of the spirochete flagellar hook as a test case
The inhibition of a specific protein-protein interaction is often difficult to achieve in targeted drug design. We report the development and optimization of a general-purpose, readily implemented enzyme-linked immunosorbent assay (ELISA) for high-throughput screening to identify small-molecule inhibitors of protein interactions. This ELISA does not involve the use of any capture antibodies, probes, or compounds […]
Caring Under Pressure: A Qualitative Study of Nurse Job Satisfaction in a Private Hospital in Nigeria
Using the Herzberg’s Two-Factor Theory, this study explored factors influencing job satisfaction among nurses in a private hospital in Nigeria. Ten nurses were recruited through purposive sampling to participate in interviews. Data was analyzed in MAXQDA using a thematic analysis approach. Extrinsic (hygiene) factors (i.e., high workload, low salary, limited opportunities for career advancement) were […]
Sex-specific genetic regulation of proteomics in cerebrospinal fluid uncovers genetic causes for sex differences in neurodegeneration
Sex-specific genetic regulation of cerebrospinal fluid (CSF) protein levels may contribute to differential vulnerability to neurodegenerative diseases. To systematically identify sex differences in the genetic regulation of CSF proteome and their link to neurodegeneration, we performed sex-stratified pQTL analysis of 6,361 proteins in 1,713 males and 1,640 females, separately. We identified 1,729 pQTLs significant in […]
Second-line therapy following osimertinib in metastatic EGFR-mutated non-small cell lung cancer at an academic medical center
Purpose: FLAURA2 demonstrated that adding chemotherapy to osimertinib improved overall survival compared with osimertinib monotherapy in metastatic epidermal growth factor receptor mutated (EGFR-mut) non-small cell lung cancer (NSCLC). Notably, only 60% of patients in the osimertinib monotherapy arm received second-line therapy after discontinuing first lline osimertinib, raising the concern that FLAURA2 did not accurately reflect […]
What is the effectiveness of interventions to support the mental and emotional health and wellbeing of young people who are not in education, employment or training (NEET)? A Rapid Evidence Review
Mental health problems among young people have continued to rise over the last decade. Support services are available in higher education and in many workplace environments. However, while approaches to maintain or enhance mental health and wellbeing within these settings are valuable, it is important to understand what alternative community-based supportive measures or interventions are […]
Reinforcement of speciation by behavioural and reproductive barriers in the Drosophila bipectinata species complex
Speciation mainly depends on different mechanisms involved in reproductive isolation; Understanding such barriers that consistently develop to avoid the fitness cost through reinforcement until the speciation continuum completes helps clarify the role of pre-mating and post-mating isolating mechanisms. The Drosophila bipectinata species complex, comprising four closely related taxa, provides a natural system for studying the […]