Eukaryotic circular RNAs (circRNAs) perform a wide variety of functions. A subset of circRNAs has been demonstrated to undergo translation in vivo. However, few insights exist on the underlying translation mechanisms. Here, we elucidate the basis of translation initiation in two naturally occurring circular RNAs, circMbl and circSfl. We show that in vitro prepared versions […]

Australia’s Quaternary fossil record is characterised by a high diversity of macropodid taxa. Based on fossil faunal assemblages, it has been hypothesised many macropodids lived in sympatry during the Pleistocene, however, local geographic and dietary overlap is equivocal due to taphonomic uncertainty. Modern macropodid species rarely exhibit sympatry, suggesting anthropogenic or environmental changes may have […]

Acute myeloid leukemia (AML) is the most common leukemia in adults and current methods rely on cytogenic and molecular profiling for AML classification and risk stratification. Recent advances have demonstrated that next generation sequencing (NGS) may improve prognostic prediction and risk stratification of AML patients. A tumor-only high coverage (~220x) whole genome sequencing (WGS) method […]

Honey bees rely on bacterial symbionts for their nutritional needs and for protection against invading pathogens. Genetic diversity among strains within the colony has the potential to impact symbiont function and subsequently the benefits that honey bees receive from them. Mobilized genes vectored by mobile genetic elements (MGEs) like phages, transposons, conjugative elements and plasmids, […]

Background High workload among general practitioners (GPs) poses a growing challenge to clinician well-being and care quality. Ambient scribes offer a potential solution, but evidence on their effectiveness is limited and largely overlooks the patient perspective. Methods A prospective multicentre multi-perspective before-after longitudinal mixed-methods study with 12 GPs and GPs in training without prior experience […]

Vibrio cholerae is a ubiquitous marine microbe that solubilizes and consumes chitin in the marine water column. In both the marine environment and the intestinal track, V. cholerae forms biofilms; a key question regarding the lifestyle of V. cholerae is how do the diverse substrates that it encounters influence its biofilm formation and, in turn, […]

Introduction: Despite significant progress in perinatal care, intrapartum related asphyxia remains a leading cause of neonatal morbidity and mortality, especially in the poorest regions of the world such as sub-Saharan Africa. The objective of this study is to determine the prevalence, risk factors, and adverse outcomes of intrapartum related asphyxia among low risk health facility […]

Diatoms are globally significant microalgae that contribute ~20% of oxygen production and exhibit remarkable metabolic diversity. The marine diatom Phaeodactylum tricornutum has emerged as a promising synthetic biology platform for bioproduction of recombinant proteins, supported by a human-like N-linked glycosylation pathway. However, its (1,3)-linked core fucose is immunogenic in humans and thus limits biopharmaceutical applications. […]

While the earliest pathological signs of cardiovascular disease (CVD) emerge before age 20, current adult-based risk thresholds fail to identify a substantial fraction of high-risk children. With the rising prevalence of childhood obesity, the need for early and sensitive detection of cardiovascular-kidney-metabolic disease (CKMD) risk is paramount to enable timely intervention that can prevent the […]

Human cytomegalovirus (HCMV) is a leading cause of congenital infection and morbidity in immunosuppressed populations. Like all viruses, HCMV is an obligate intracellular parasite that extensively remodels host cellular metabolism to support its replication, yet the precise underlying mechanisms and metabolic vulnerabilities remain poorly understood. Using a novel metabolism-focused screening platform, we identified EGLN prolyl […]