Objectives: Mental health services are facing unprecedented demand, placing significant pressure on clinicians to conduct timely and effective patient assessments. Rising staff turnover and burnout threatens service quality across many countries. This study examined whether providing clinical information, collected via an AI-enabled decision support tool for mental health assessments in the UK National Health Service […]
Genome-scale CRISPRi profiling reveals metabolic vulnerabilities of uropathogenic Escherichia coli in human urine
Urinary tract infections (UTIs) are among the most common infectious diseases, causing over 400 million cases and 260,000 deaths annually. Women are disproportionately affected, with ~50% experiencing at least one UTI during their lifetime and 20-30% suffering from recurrent infections. Uropathogenic Escherichia coli (UPEC), which accounts for ~75% of cases, employs diverse virulence factors to […]
Comparison of IFSG to SOC for treatment of venous leg ulcers using real-world data from the USWR with 1:1 matching on 14 wound/patient factors
Background: Venous leg ulcers (VLUs) impose substantial morbidity and Medicare spending, yet many real world ulcers remain refractory to standard of care (SOC). Intact fish skin graft (IFSG) is a biologic tissue graft used for chronic wounds. We evaluated the comparative effectiveness of IFSG versus SOC in routine practice using a specialty wound registry with […]
Mitochondrial uncoupler BAM15 improves skeletal muscle function and mitochondrial respiration in Sarcopenia
Background: Ageing is accompanied by progressive declines in skeletal muscle mass and strength, culminating in sarcopenia, a condition that contributes to frailty, multimorbidity, and mortality. Age-related changes to mitochondria lead to oxidative damage and dysfunction and are proposed to occur early in the trajectory of sarcopenia, supporting the candidacy of mitochondrial-protective therapies. Here, we test […]
Evaluation of Intact Fish Skin Grafts Plus Standard Care in the treatment of Venous Leg Ulcers: an interim analysis of the THOR trial.
Background: Venous leg ulcers (VLUs) are nonhealing wounds that pose considerable clinical and economic challenges. Healing outcomes with existing standard of care (SOC) remain limited, creating a pressing need for more effective therapeutic options Methods: An interim analysis of this randomized controlled multicenter clinical trial evaluated in-tact fish skin graft (IFSG) and SOC versus SOC […]
Harnessing Alpine Lake Bacteria for the Development of Synthetic Communities with Broad-Spectrum Antiviral Activity
In aquatic ecosystems, phagotrophic protists and bacteriophages are major biological factors shaping bacterial populations. However, the extreme environmental conditions and low nutrient concentrations in alpine lakes limit the abundance of protists. Thus, bacteriophages may represent the main biological factor shaping bacterial communities in these ecosystems. We hypothesized that alpine lake bacteria populations harbor diverse antiviral […]
Electrolyte Imbalance in Asphyxiated Term Neonates: Incidence, Predictors, and Outcomes from a Prospective Cohort study in Northern Uganda.
Background Birth asphyxia is a major cause of neonatal morbidity and mortality, particularly in low-resource settings. Hypoxia and metabolic derangements that occur during asphyxia predispose neonates to electrolyte abnormalities, which may worsen the clinical course and contribute to poor outcomes. Early recognition and management of such imbalances can improve survival and prevent long-term neurological damage. […]
COTree: A Statistical Framework for Deciphering Cell-Resolved Multi-Omics Trajectories
Recent advances in whole-cell modeling enable the computational tracking of the temporal evolution of thousands of molecular species across genomic, transcriptomic, proteomic, and metabolomic layers. These models provide a complementary perspective for studying cellular dynamics, offering continuous, system-wide observations that are difficult to obtain from experimental technologies, which are often destructive and yield only static […]
Association between Depression and Quality of Life among the aging population in Bharatpur Metropolitan City, Nepal
Background: Depression and quality of life (QoL) are major concerns among the elderly. This study aimed to evaluate the prevalence of depression and its relationship with QoL among older adults in Bharatpur Metropolitan City, Nepal. Methods: A community-based cross-sectional study was conducted from February 2024 to July 2025 involving 250 elderly participants aged [≥] 60 […]
Golden Promise-rapid, a fast-cycling barley genotype with high transformation efficiency
The spring barley cultivar Golden Promise (GP) is the major reference genotype for transformation due to its high transformability and availability of a reference genome. However, GP is characterized by a long generation cycle and stress susceptibility under non-optimal growth conditions because it carries a mutation at the floral inducer Photoperiod-H1 (Ppd-H1). Previously, we showed […]