arXiv:2411.06635v4 Announce Type: replace-cross Abstract: Single-cell RNA sequencing enables high-resolution analysis of cellular heterogeneity, yet disentangling biological signal from batch effects remains a major challenge. Existing batch-correction algorithms suppress or discard batch-related variation rather than modeling it. We propose scMEDAL, single-cell Mixed Effects Deep Autoencoder Learning, a framework that separately models batch-invariant and batch-specific effects […]
Pragmatic Reasoning improves LLM Code Generation
arXiv:2502.15835v3 Announce Type: replace-cross Abstract: Large Language Models (LLMs) have demonstrated impressive potential in translating natural language (NL) instructions into program code. However, user instructions often contain inherent ambiguities, making it challenging for LLMs to generate code that accurately reflects the user’s true intent. To address this challenge, researchers have proposed approaches that produce multiple […]
TathyaNyaya and FactLegalLlama: Advancing Factual Judgment Prediction and Explanation in the Indian Legal Context
arXiv:2504.04737v2 Announce Type: replace-cross Abstract: In the landscape of Fact-based Judgment Prediction and Explanation (FJPE), reliance on factual data is essential for developing robust and realistic AI-driven decision-making tools. This paper introduces TathyaNyaya, the largest annotated dataset for FJPE tailored to the Indian legal context, encompassing judgments from the Supreme Court of India and various […]
Learning Dynamics of RNNs in Closed-Loop Environments
arXiv:2505.13567v2 Announce Type: replace-cross Abstract: Recurrent neural networks (RNNs) trained on neuroscience-inspired tasks offer powerful models of brain computation. However, typical training paradigms rely on open-loop, supervised settings, whereas real-world learning unfolds in closed-loop environments. Here, we develop a mathematical theory describing the learning dynamics of linear RNNs trained in closed-loop contexts. We first demonstrate […]
Two Causally Related Needles in a Video Haystack
arXiv:2505.19853v3 Announce Type: replace-cross Abstract: Properly evaluating the ability of Video-Language Models (VLMs) to understand long videos remains a challenge. We propose a long-context video understanding benchmark, Causal2Needles, that assesses two crucial abilities insufficiently addressed by existing benchmarks: (1) extracting information from two separate locations (two needles) in a long video and understanding them jointly, […]
Shared Spatial Memory Through Predictive Coding
arXiv:2511.04235v1 Announce Type: new Abstract: Sharing and reconstructing a consistent spatial memory is a critical challenge in multi-agent systems, where partial observability and limited bandwidth often lead to catastrophic failures in coordination. We introduce a multi-agent predictive coding framework that formulate coordination as the minimization of mutual uncertainty among agents. Instantiated as an information bottleneck […]
Patient in Intellia CRISPR trial dies after being hospitalized with liver injury
A man in his early 80s who was recently hospitalized with liver injury, a few weeks after receiving an experimental gene editing therapy, died on Wednesday …
Evommune CEO talks about sticking with $150M IPO plan during government shutdown
More biotech IPOs have occurred during the government shutdown than during a seven-month industry dry spell from February to September. On Thursday, inflammatory disease biotech Evommune raised $150 million in its initial public offering. Its …
Zuckerberg-backed Biohub hires EvolutionaryScale team in apparent end of AI startup
EvolutionaryScale made waves with its launch last year, raising a $142 million seed round to build some of the biggest AI models that biology has ever seen. Now it appears that the …
Author Correction: Integrating digital gait data with metabolomics and clinical data to predict outcomes in Parkinson’s disease
npj Digital Medicine, Published online: 07 November 2025; doi:10.1038/s41746-025-02098-9 Author Correction: Integrating digital gait data with metabolomics and clinical data to predict outcomes in Parkinson’s disease