npj Digital Medicine, Published online: 07 November 2025; doi:10.1038/s41746-025-02113-z With a growing number of studies applying generative artificial intelligence (GAI) models for health purposes, reporting standards are being developed to guide authors in this space. We describe the currently available reporting guidelines that apply to GAI models and provide an overview of upcoming reporting standards. […]
A generalizable 3D framework and model for self-supervised learning in medical imaging
npj Digital Medicine, Published online: 07 November 2025; doi:10.1038/s41746-025-02035-w A generalizable 3D framework and model for self-supervised learning in medical imaging
Humanitarian Perspectives on Civilian Shelter Guidance in Armed Conflict Zones: A Qualitative Study
Objectives The widespread use of explosive weapons in populated areas (EWIPA) has become a defining feature of modern conflict, with devastating consequences for civilians. Practical guidance on civilian sheltering during explosive attacks remains limited, inconsistent, and lacking in scientific evidence. This study explored the current landscape of shelter guidance through the perspectives of humanitarian practitioners […]
Sex-based differences in the prevalence and determinants of anaemia among children living with HIV Southern Province of Zambia
Background: anaemia remains a major comorbidity among children living with HIV (CLHIV) in sub-Saharan Africa, yet sex-specific risk factors are poorly characterized. This study investigated the prevalence and sex-based determinants of anaemia among CLHIV in the Southern Province, Zambia. Methods: A retrospective cohort study was conducted using medical records from 321 CLHIV aged 0-14 years. […]
Identifying Multi-omics Signatures that characterize Responders to Plant-based Dietary Interventions
Metabolic responses to dietary interventions often show high inter-individual variations, but the factors explaining these variations as well as underlying mechanisms and their interrelation remain largely unknown. Knowing which factors are relevant for the individual response to a dietary intervention and to which extent, is essential to provide targeted dietary recommendations. Therefore, in persons at […]
Wide-awake local anaesthesia no tourniquet hand surgery in Australia: an analysis of adoption, perceptions, and implementation in a global context
Background: Wide-awake local anaesthesia no tourniquet (WALANT) is increasingly used globally for hand surgery, offering clinical and operational benefits. However, its adoption in Australia remains understudied. This study assessed current WALANT usage among Australian hand surgeons to identify key factors influencing its implementation. Methods: A national cross-sectional survey of all Australian Hand Surgery Society (AHSS) […]
Selective reporting of outcomes and results in interrupted time series studies of health interventions: a methodological study
Objective: Selective reporting bias occurs when authors report outcomes or results based on the P value, magnitude or direction of the results. Selective reporting has not been examined in interrupted time series (ITS) studies. Therefore, we investigated (1) discrepancies in outcome reporting, (2) completeness of results reporting, and (3) evidence of selective reporting bias in […]
The Role of Linker Length and Composition in Actin Binding and Bundling by Palladin
Interdomain linkers in multidomain proteins influence spatial arrangement, flexibility, and cooperative binding, yet their functional roles remain underexplored. Palladin, an actin scaffold protein essential for cytoskeletal organization, contains tandem immunoglobulin domains (Ig3-4) separated by an unusually long (41-residue), arginine-rich, intrinsically disordered linker. While Ig3 mediates direct F-actin binding, the adjacent Ig4 domain and linker enhance […]
High-salt diet disturbs the physiological uterine endothelial junction remodeling during pregnancy
A high-salt diet (HSD) induced excessive sodium intake is a major risk factor for various diseases. However, its specific effects on uterine endothelial cell and pregnancy outcomes remain poorly understood. In this study, we demonstrated that HSD induces gestation specific hypertension and adverse pregnancy outcomes in murine models. The proper spiral artery remodeling, which involved […]
A Sequential Triple-Drug Strategy for Selective Targeting of p53-Mutant Cancers
The tumor suppressor TP53 gene (p53) is mutated in most human malignancies but existing treatment options are largely ineffective, lack selectivity, and cause toxic side effects. To address these clinical problems, we have developed a two-drug treatment that induces lethal DNA damage and G2-arrest in p53 mutant cancer cells. Here, we present a triple-drug therapeutic […]