Engagement in interaction arises through the continuous monitoring of conversation content, allowing individuals to prioritize information that is most relevant to them. Emotional salience of semantic content may play a key role in guiding this attentional engagement. By combining audiovisual ‘Cocktail-party’ – paradigm with source-localized magnetoencephalography and encoding-decoding models, we examined how emotional salience and […]

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a baffling disease. The disease has a wide spectrum of severity, to date has no established molecular marker, no known causation, and no cure. Many patients report in retrospect that they suffered a virus infection prior to suffering their first symptoms of ME/CFS. Therefore, we report a search for […]

Multicellularity has evolved dozens of times in many branches across the Tree of Life, in each case producing a new kind of individual that has the potential for division of labor among its constituent cells. In many of these instances, nascent multicellularity has remained facultative, manifesting only under conditions where it provides a decisive fitness […]

Introduction: Recent studies such as the EXTEND-IA, AcT, and ATTEST-2 have shown tenecteplase (TNK) may have potential advantages over alteplase for AIS. This study further evaluates the effectiveness and safety of TNK at 0.25 mg/kg IV for AIS and represents real world utilization covering a diverse population reinforcing the safety and efficacy of TNK compared […]

Histone H4K16 acetylation (H4K16ac) is a key epigenetic mark essential for chromatin structure and DNA repair, which is substantially reduced in the accelerated aging disorder Hutchinson-Gilford progeria syndrome (HGPS). The specific enzymes governing H4K16ac homeostasis, particularly the deacetylase responsible for its loss in HGPS, remain poorly defined. Here, we sought to identify the enzymes regulating […]

Microbial cell-free DNA (mcfDNA) analysis offers a novel approach for monitoring blood-borne viral infections, with prior studies highlighting its clinical utility in viral lineage characterization. However, existing research predominantly employs cross-sectional designs, lacking systematic investigation into spatiotemporal viral dynamics and host genetic regulation. Leveraging non-invasive prenatal testing (NIPT) data from 1,023,651 pregnant women in Hebei […]

Surround modulation refers to changes in neural responses to a central stimulus induced by its surrounding context, which can manifest as either suppression or facilitation. Although this phenomenon is well established for simple stimuli, its underlying neural mechanism during natural scene perception remains unclear. Using fMRI, we examined how motion congruence and categorical similarity between […]

Background Oral cholera vaccine (OCV) is a critical tool for controlling cholera outbreaks. However, the effectiveness and efficiency of reactive OCV campaigns depend strongly on implementation timing and targeting strategy. Methods Using data from 1,192 cholera outbreaks (2010-2020) in sub-Saharan Africa, we conducted stochastic simulations of single-dose OCV outbreak response immunization (ORI) strategies varying by […]

Understanding bumble bee gut health is imperative as these vital pollinators are subjected to pathogenic infections and thermal stress from climate change. The gut microbiome serves as an indicator for health and fitness and indicates the types of stress. To investigate the combined effects of thermal stress and pathogenic infection on bee guts, we performed […]

Diagnostic testing delays worsened during the COVID-19 pandemic, but it is unclear whether geographic inequalities have deepened. Using publicly-available data in England for nine tests, we compared waiting times across 106 local areas in 2019 and 2024/25. The national median proportion of patients waiting over six weeks increased from 2.2% to 18.8%, while geographic variation […]