Fortification of human milk (HM) is essential to meet the nutritional needs of very low birthweight infants (VLBWI). Most available fortifiers are derived from cows milk, raising concerns about tolerability, immunogenicity and access in low-resource settings. LioNeo is a novel multinutrient fortifier produced exclusively from freeze-dried donor HM by a certified Human Milk Bank in […]
Predicting 7-Day Re-Bleeding after Peptic Ulcer Hemostasis: Retrospective Analysis of Forrest, Complete Rockall, and Glasgow-Blatchford Scores and Independent Risk Factors
Objective To identify independent risk factors for early ([≤]7-day) re-bleeding after peptic ulcer bleeding (PUB) and to compare the predictive performance of Forrest classification, Complete Rockall Score (CRS), and Glasgow-Blatchford Score (GBS). Methods We retrospectively analyzed adults with endoscopy-confirmed peptic ulcer bleeding from 2015-2020. Early re-bleeding was defined as [≤]7 days after index hemostasis. We […]
Loneliness and Cognitive Decline Among U.S. Adults: A Stratified Analysis of the BRFSS
Background Loneliness is an emerging public health concern linked to adverse mental and physical outcomes. It may play a key role in cognitive aging, yet its population-level association with subjective cognitive decline (SCD) across demographic groups is not well characterized. We evaluated how the frequency of loneliness relates to SCD in U.S. adults and whether […]
Outcome Evaluation of the M-Mama Emergency Transport System (EmTS) and Factors Associated with its Utilisation among Lactating Mothers in Kigoma District Council
Abstract Background: Sub-Saharan Africa accounts for approximately 70% of maternal deaths worldwide. In Tanzania, the maternal mortality ratio (MMR) has decreased from 556 deaths per 100,000 live births in 2016 to 104 deaths per 100,000 live births in 2022. The major cause of these deaths is limited access to emergency obstetric care. To address this […]
The Impact of Craniotomy and Surgical Fixation Devices on the Efficacy of Tumor Treating Fields in Glioblastoma Treatment
Glioblastoma is increasingly treated with Tumor Treating Fields (TTFields), but how post-craniotomy anatomy and fixation hardware alter delivered fields is unclear. We used finite-element modeling in a realistic head model to simulate TTFields after a standard bone flap with either a non-penetrating fixation plate or a penetrating skull clamp, and compared results to an intact- […]
Maternal dietary diversity and its correlates in a semi-urban municipality of Nepal: A cross-sectional study
Maternal dietary diversity is vital for the health of both mother and child during lactation yet often compromised in low- and middle-income countries. This cross-sectional study among 251 lactating mothers in Tarakeswor Municipality, Nepal, assessed dietary diversity using a 24-hour recall and the Minimum Dietary Diversity for Women (MDD-W) indicator. Overall, 68.1% of mothers achieved […]
Maternal dietary diversity and its correlates in a semi-urban municipality of Nepal: A cross-sectional study
Maternal dietary diversity is vital for the health of both mother and child during lactation yet often compromised in low- and middle-income countries. This cross-sectional study among 251 lactating mothers in Tarakeswor Municipality, Nepal, assessed dietary diversity using a 24-hour recall and the Minimum Dietary Diversity for Women (MDD-W) indicator. Overall, 68.1% of mothers achieved […]
The Impact of Craniotomy and Surgical Fixation Devices on the Efficacy of Tumor Treating Fields in Glioblastoma Treatment
Glioblastoma is increasingly treated with Tumor Treating Fields (TTFields), but how post-craniotomy anatomy and fixation hardware alter delivered fields is unclear. We used finite-element modeling in a realistic head model to simulate TTFields after a standard bone flap with either a non-penetrating fixation plate or a penetrating skull clamp, and compared results to an intact- […]
Varied monoamine reuptake inhibitors reduce parvalbumin expression; implications for pyramidal cell disinhibition and enhanced neuroplasticity
First-line antidepressants are effective in a significant percent of individuals but a full understanding of how these therapeutics target specific endpoints is lacking. Prior work has shown that depression is associated with hippocampal atrophy and that antidepressants can increase neurotrophin levels to increase hippocampal neurogenesis as well as hippocampal pyramidal cell (PC) spine density and […]
A subject-specific reversible folding model reveals geometry-driven white-matter organization
Tractography currently relies almost exclusively on diffusion data and seed maps, which alone remain insufficient for anatomically accurate fiber reconstruction. During brain development, white-matter fibers elongate alongside cortical folding, suggesting a close mechanistic link between cortical geometry and fiber organization. To investigate this link, we introduce a subject-specific cortical folding simulation framework that reconstructs an […]