Motile cilia coordinate fluid flows that are essential for normal tissue physiology and function. Cilia display diverse beating waveforms, and while pronounced defects are strongly associated with motile ciliopathies, more subtle alterations may also influence disease manifestations. Finer quantification of ciliary dynamics is critical for a full understanding of cilia-associated disorders, but the heterogeneity of […]
Beta2* Nicotinic Receptors Tune Prefrontal Behavior Through Distinct Neuronal Populations
Nicotinic acetylcholine receptors containing beta2 subunit (beta2* nAChRs) are widely expressed in the mouse prefrontal cortex (PFC), where they regulate behavioral and cognitive domains associated with this region and represent potential therapeutic targets for neuropsychiatric symptoms. However, current pharmacological tools cannot distinguish among receptors expressed by different neuronal populations, and the functional roles of beta2* […]
Over-Reliance on Prior Expectations in Relapsing-Remitting Multiple Sclerosis
Cognitive impairment is a common and disabling feature of multiple sclerosis (MS). Bayesian models of perception and action provide a powerful framework to better understand how cognitive processes are altered in MS. In this study, we employed a time reproduction paradigm within a Bayesian framework to investigate the underlying mechanisms of cognitive dysfunction in patients […]
Divergent myelopoiesis and macrophage polarization underlie host susceptibility to chronic Chlamydia trachomatis infection
Chronic genital infection with Chlamydia trachomatis is associated with immune suppression and pathogen persistence, but the mechanisms underlying this phenomenon remain poorly defined. Here, we show that chronic C. trachomatis genital infection differentially reprograms myelopoiesis and macrophage polarization in genetically distinct mouse strains. In BALB/c mice, infection expanded bone marrow progenitors with enhanced colony-forming potential […]
Over-Reliance on Prior Expectations in Relapsing-Remitting Multiple Sclerosis
Cognitive impairment is a common and disabling feature of multiple sclerosis (MS). Bayesian models of perception and action provide a powerful framework to better understand how cognitive processes are altered in MS. In this study, we employed a time reproduction paradigm within a Bayesian framework to investigate the underlying mechanisms of cognitive dysfunction in patients […]
Beta2* Nicotinic Receptors Tune Prefrontal Behavior Through Distinct Neuronal Populations
Nicotinic acetylcholine receptors containing beta2 subunit (beta2* nAChRs) are widely expressed in the mouse prefrontal cortex (PFC), where they regulate behavioral and cognitive domains associated with this region and represent potential therapeutic targets for neuropsychiatric symptoms. However, current pharmacological tools cannot distinguish among receptors expressed by different neuronal populations, and the functional roles of beta2* […]
Cilia.io: Computer vision and machine learning reveal spatial patterns of cilia beating dynamics in the spinal cord
Motile cilia coordinate fluid flows that are essential for normal tissue physiology and function. Cilia display diverse beating waveforms, and while pronounced defects are strongly associated with motile ciliopathies, more subtle alterations may also influence disease manifestations. Finer quantification of ciliary dynamics is critical for a full understanding of cilia-associated disorders, but the heterogeneity of […]
Divergent myelopoiesis and macrophage polarization underlie host susceptibility to chronic Chlamydia trachomatis infection
Chronic genital infection with Chlamydia trachomatis is associated with immune suppression and pathogen persistence, but the mechanisms underlying this phenomenon remain poorly defined. Here, we show that chronic C. trachomatis genital infection differentially reprograms myelopoiesis and macrophage polarization in genetically distinct mouse strains. In BALB/c mice, infection expanded bone marrow progenitors with enhanced colony-forming potential […]
Human cortical networks trade communication efficiency for computational reliability.
Brains are often described as cost-efficient communication networks, optimally balancing the cost of long connections with the benefits of fast communication. Here, inspired by the "use it or lose it" principle, we present a novel game-theoretic model of self-organizing neural units and show that the brain is, in fact, sub-optimal in both regards: First, we […]
A Novel Patient-Derived Mutation in Glucocorticoid Receptor Reveals an Essential Role for DNA binding in Development and Endocrine Regulation
Glucocorticoid receptors (GRs) are vital transcription factors regulating stress responses, metabolism, and development. We report here a novel heterozygous NR3C1 c.1310C>T (p.T437I) variant within the GR DNA-binding domain found in a family exhibiting clinical and hormonal manifestations of partial glucocorticoid resistance. Patient-derived fibroblasts demonstrated an overall suppression in dexamethasone-induced transcription. To comprehensively assess the significance […]