Tissues develop and function within a highly complex microenvironment, where diverse cell types interact in tightly regulated spatial and temporal patterns. Through distinct, relay-like waves of activity, these cells collectively shape tissue formation, ensuring that each component emerges in the right place at the right time. Such coordinated cues establish the structural and biochemical framework […]

For a long time, working memory was considered to reflect sustained activity in prefrontal and parietal areas. This has been challenged by the "sensory recruitment model" according to which sensory areas are involved in maintaining working memory representations. The main support for this comes from the finding that working memory contents can be decoded from […]

Many studies have analyzed what organizational features distinguish the left and right hemispheres of the human brain, with most differences typically being found in language areas. In this analysis, we test whether supervised learning can categorize an unseen hemisphere as right or left based on functional connectivity. Using data from the Human Connectome Project, we […]

Introduction: Extracellular vesicles (EVs) mediate intercellular communication in the central nervous system (CNS) and are emerging as biomarkers of brain health and disease. However, the molecular composition of cell type-specific brain EVs, particularly astrocyte-derived EVs (ADEVs), remains poorly defined. Methods: We performed comparative proteomic analysis of neuronal (NDEVs), microglial (MDEVs), and astrocytic (ADEVs) from mouse […]

Heterozygous loss-of-function mutations in SCN2A, a sodium channel gene expressed in cortical pyramidal (PYR) cells, lead to a neurodevelopmental disorder characterized by autism, intellectual disability, and cortical sensory dysfunction. In Scn2a+/- mice, PYR dendritic excitability and synapses are impaired, but cortical information processing deficits are unknown. In the whisker somatosensory cortex, we found strongly degraded […]

Silent visual reading is accompanied by the phenomenological experience of an inner voice. However, the temporal dynamics and functional role of the underlying neural representations remain unclear. Here, we recorded electroencephalography (EEG) data while humans read naturalistic narratives, and applied computational modelling to isolate time-resolved auditory from visual and semantic representations. Our results revealed robust […]

Human speech carries information beyond the words themselves: pitch, loudness, duration, and pauses–jointly referred to as ‘prosody’–emphasize critical words, help group words into phrases, and convey emotional and other socially-relevant information. Using a novel fMRI paradigm, we identify a set of prosody-responsive brain areas and then richly characterize them across 8 experiments (25 experimental conditions; […]