Background: The rest-activity rhythm amplitude (RARA), as a fundamental human behavior, has been linked to various health conditions. However, its causal relationship with ischemic heart disease (IHD), along with the potential modification by genetic predisposition, remains unclear. Objective: This study aimed to investigate the causal association between RARA and IHD using a triangulation approach that […]
Multimodal Data–Driven Explainable Prognostic Model for Major Adverse Cardiovascular Events Prediction in Patients With Unstable Angina and Heart Failure With Preserved Ejection Fraction: Multicenter, Cross-Regional Cohort Study
Background: Heart failure with preserved ejection fraction (HFpEF) and unstable angina (UA) often coexist in clinical practice, constituting a high-risk cardiovascular phenotype with a markedly increased incidence of major adverse cardiovascular events (MACEs). Identification of high-risk patients within this population is crucial for reducing complications, improving outcomes, and guiding clinical decision-making. Objective: This study aimed […]
Apple Patches More Zero-Days Used in ‘Sophisticated’ Attack
Two Apple zero-day vulnerabilities discovered this month have overlap with another mysterious zero-day flaw Google patched last week.
Lenz discloses case of retinal tear in presbyopia eye drop patient
Lenz Therapeutics alarmed investors on Friday when it disclosed a report of a serious complication in a patient who took its commercial eye drop for blurry near vision. The drug, called Vizz, was
FDA wants to use more real-world data and calls again for early-phase trials reform
The FDA will consider more real-world data in drug and device applications, including from large datasets that don’t have identifiable patient data, Commissioner Marty Makary told a Wall Street audience on Monday in New York …
Enhertu combo wins FDA approval for first-line use in metastatic breast cancer
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Mobile Phone Messaging–Based Interventions to Improve Physical Activity in Patients With Cancer: Systematic Review and Meta-Analysis
Background: Despite the benefits of physical activity for improving cancer-related outcomes, the majority of patients with cancer fail to meet physical activity guidelines. Mobile phone messaging is a scalable approach for promoting physical activity, but its effect on improving physical activity among cancer patients has not been reviewed. Objective: To systematically evaluate the effects of […]
Think Like an Attacker: Cybersecurity Tips From Cato Networks’ CISO
Etay Mayor, a cybersecurity strategist and professor, shares his journey, insights, and advice on breaking into the diverse and ever-evolving field of cybersecurity.
FDA speeds up review of J&J’s multiple myeloma combo treatment following positive data
Johnson & Johnson’s Tecvayli and Darzalex combination treatment scored another win in second-line multiple myeloma, with the FDA moving with unprecedented speed after the latest data to issue a new voucher that expedites the combo’ …
With GLP-1 microdoses, Noom targets lower-BMI group outside FDA obesity drug labels
The telehealth company Noom plans to target people with a body mass index well below the requirements for FDA-approved obesity shots, using a microdose GLP-1 offering. The strategy is becoming more common, as online health …