Longitudinal Effects of a Smartphone Game (Tumaini) for HIV Prevention Among Kenyan Adolescents: 45-Month Trajectories of Condom Use–Related Proximal Outcomes From a Randomized Controlled Trial

Background: African adolescents and young adults account for a disproportionate number of new HIV infections. There is an urgent need to identify scalable and cost-effective behavioral HIV prevention strategies for this population. Using a condom at first sex is associated with a higher likelihood of consistent use later. Tumaini (“Hope for the Future” in Swahili; […]

Effects of Internet-Based Dementia Risk Reduction Education on Risk and Protective Factor Knowledge, Intentions, and Health Behaviors: Randomized Controlled Trial

Background: Dementia prevention through the reduction of modifiable risk factors is gaining attention as a public health strategy. However, public knowledge of dementia risk and protective factors remains low. Web-based education offers a potential solution to raise awareness and promote risk-reduction behaviors. Objective: This randomized controlled trial evaluated the effectiveness of DementiaRisk.ca, an internet-based multimedia […]

Digital Peer Support to Increase Walking Among Older Adults: Cluster Randomized Trial

Background: As the population ages, older adults face an increasing risk of physical inactivity and related health complications, highlighting the need for scalable interventions. Smartphone-based programs have emerged as a promising strategy to support sustained physical activity among older adults. Objective: This study aimed to evaluate whether a smartphone lecture program incorporating a digital peer […]

Breast Cancer Screening Knowledge and Sentiments in Singaporean Women: Mixed Methods Study Using Topic Modeling, Sentiment Analysis, and Structured Questionnaire Data

Background: Mammography screening uptake in Singapore remains below 40% despite campaigns and subsidies. Natural language processing (NLP) can extract nuanced attitudes from free text that fixed response options miss, revealing latent factors influencing breast cancer (BC) screening behavior. Objective: This study characterized women’s attitudes toward mammography using mixed methods data, examined associations between BC awareness […]

Investigating the Effect of Hospital Infection Control Informatization on Optimizing Microbiological Specimen Submission Before Antibiotic Therapy: Failure Mode and Effects Analysis

Background: Antimicrobial resistance (AMR) poses a critical global health threat, with inappropriate antibiotic use being a major driver. Timely microbiological specimen submission before initiating antibiotic therapy is a cornerstone of antimicrobial stewardship (AMS), enabling pathogen-directed therapy and reducing unnecessary broad-spectrum exposure. However, suboptimal compliance remains common due to workflow interruptions, technological barriers, and behavioral factors. […]

eHealth Literacy and Type 2 Diabetes Prevention Among At-Risk Populations: Mechanistic Systematic Review Using Theory-Driven Thematic Analysis

Background: Type 2 diabetes (T2D) is emerging as a growing global public health crisis. Early and effective interventions can reduce T2D incidence among at-risk populations. Compared with traditional approaches, digital health technologies offer promising opportunities for prevention, with eHealth literacy (eHL) emerging as a critical determinant of digital prevention outcomes. Objective: This systematic review aims […]

Quality Challenges in Municipal Telecare Call Center Services: Qualitative Evaluation Using the Anchored, Realistic, Cocreated, Human, Integrated, and Evaluated (ARCHIE) Framework

Background: Telecare is seen as a promising technology aimed at enhancing the accessibility and efficiency of health care services. Although focus on quality has been highly prioritized within the health care services, there is a need to explore the quality of telecare services in general and municipal telecare call centers (CCs) in particular, as health […]

A cross-sectional analysis of AI readiness and attitudes among nurses in resource-limited Chinese county hospitals

AimTo investigate the current situation of clinical nurses’ attitudes towards artificial intelligence in county hospitals and analyze its influencing factors, so as to provide a reference for promoting the application of artificial intelligence technology in the field of primary medical care.DesignA descriptive, cross-sectional study.MethodsA total of 449 clinical nurses from a Chinese county-level B-level hospital […]

A digital twin framework for predicting and simulating type 2 diabetes onset using retrospective lifestyle data

IntroductionType 2 Diabetes Mellitus (T2DM) is a rising global health concern, heavily influenced by modifiable lifestyle and psychosocial factors. However, most predictive tools focus on biomedical markers and rely on real-time data from wearables or electronic health records, limiting their scalability in resource-constrained settings. This study presents a novel digital twin (DT) framework that uses […]

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