This paper explores the perspectives of stakeholders involved in federated networks for health data sharing, focusing on the legal and practical dimensions of data protection and governance under GDPR and EHDS in the development of such infrastructures. Using a qualitative approach centered on perspectives of 19 experts with experience in projects building federated networks, it […]
Structuring integration for patient-centered care: a review-informed ontology-driven modular front-end framework for digital health innovation
BackgroundSemantic interoperability remains a significant barrier in healthcare, particularly when integrating patient-reported, clinical, and genomic data to enable personalized care. Existing models rarely focus on patient-centered, ontology-driven front-end architectures based on widely adopted standardized medical ontologies and terminologies. Within broader Personal Health Data Space (PHDS) initiatives, such integration increasingly depends on front-end frameworks that enable […]
Decoding perceived risks in online healthcare services: a safety–trust model based on grounded theory
IntroductionThe rapid rise of online healthcare services (OHSs) in China has improved access to medical information and services while creating new uncertainties related to quality, security, and trust. This study aims to deepen the understanding of perceived risk in OHSs and provide empirical guidance for digital health governance, patient safety strategies, and the development of […]
From bedside to bytes: the digital transformation of the healthcare workforce
Digital transformation is reshaping healthcare work, whereas research on workforce implications remains fragmented across disciplines. Effects like burnout, resistance, and workflow disruption are often framed as implementation failures rather than systematic outcomes of how work is reorganized. This Mini Review advances a four-dimensional analytical lens distinguishing work execution (task distribution, sequencing, temporal organization), work experience […]
AI-enabled cardiovascular devices: a lifecycle playbook for evidence, change control, and post-market assurance
AI-enabled cardiovascular devices are increasingly used in imaging, physiological signal analysis, and clinical decision support systems. Despite growing clinical adoption, requirements for evidence generation, software change management, and post-deployment assurance remain fragmented across jurisdictions and are often difficult to translate into operational processes within healthcare organizations. This review synthesizes common foundations of software as a […]
An in-home engagement and usability study of GeRI: an open-source platform for remote symptom assessment and wearable activity monitoring in men with prostate cancer
Geriatric assessment (GA) is underused in oncology because clinic-based implementation is time- and resource-intensive, limiting routine evaluation of frailty and treatment tolerance. Existing digital tools often rely on proprietary devices and closed analytic pipelines. We developed the Geriatric Remote Initiative (GeRI), an open-source platform integrating a wrist-worn accelerometer, smart scale, and tablet interface with reproducible […]
“Reimaging a triage system with midwives, for midwives”: exploring preferences for a midwife-Led triage system in South Africa through a user-centered approach
IntroductionTriage in the maternity unit is critical to ensuring the delivery of timely and appropriate care. It is regarded as an initiative to reduce maternal mortality by accelerating the provision of appropriate care at the appropriate time. However, maternity units in South Africa lack standardized triage systems. Most pregnant women often wait for hours and […]
Technology-driven diabetes care: innovation without equity?
Post Content
Promises and challenges of applying large language models in the healthcare domain
Large language models are rapidly moving from theoretical concepts to active clinical pilots. Current approaches diverge between general-purpose models, which adapt to healthcare via prompt engineering, and domain-specific models, which prioritize deep alignment with medical knowledge graphs to ensure safety. Despite reported benefits in documentation efficiency and diagnostic reasoning, significant challenges remain regarding hallucination, privacy, […]
aaKomp: Alignment-free amino acid k-mer matching for genome completeness assessment at scale
In de novo sequencing projects, genome assembly optimization requires evaluating a number of candidate assemblies to identify optimal tool parameters. Yet, current completeness assessment tools like BUSCO and compleasm require 10-80 minutes per evaluation for gigabase-scale genomes, transforming what should be rapid iteration into time-intensive processes. These tools rely on alignment-based approaches and fixed ortholog […]
Hyperactive STAT1 Promotes T Follicular Helper Type 1 Cell Differentiation to Trigger Autoimmunity
Heterozygous gain-of-function (GOF) mutations in signal transducer and activator of transcription 1 (STAT1) cause an inborn error of immunity characterized by immune dysregulation, recurrent infections and various autoimmune manifestations. However, the precise pathogenic mechanism by which STAT1 GOF contributes to autoimmunity remains elusive. In our cohort, STAT1-GOF patients exhibit biased circulating follicular helper T (cTfh) […]
The BRCA1-A complex restricts replication fork reversal-dependent DNA repair in ATM deficient cells
Ataxia Telangiectasia Mutated (ATM) kinase deficiency results in cancer susceptibility and drug sensitivity. Deficiency in either the BRCA1 interacting A complex or XRCC4/Ligase 4 confers resistance to Topoisomerase I or PARP1 inhibitors in ATM-deficient cells. This suggests that BRCA1-A directs toxicity to fork-damaging agents in ATM mutated cells vis-a-vis illegitimate end-joining. Here, we show that […]