BackgroundDigital solutions may increase sustainability in healthcare for patients undergoing total hip or knee arthroplasty (THA, TKA). Little information exists on these patients’ digital health literacy levels.ObjectiveDescribe digital health literacy in patients following THA or TKA and examine the associations between sociodemographic factors and digital health literacy levels.MethodsIn a cross-sectional survey, a total of 800 […]
Ocugen heads to Phase 3 with gene therapy for geographic atrophy
Ocugen said it will take its gene therapy for a form of vision loss into a Phase 3 trial, after reporting mixed results on Tuesday from a smaller study. The gene therapy is for patients …
Lessons from the last health tech revolution
Given his former role as US national coordinator for health IT, you might expect that Farzad Mostashari would be an AI enthusiast. But his experience overseeing the rollout of electronic health records across the country …
FDA warns ImmunityBio over misleading podcast with Patrick Soon-Shiong
The FDA warned California-based ImmunityBio for a TV advertisement and podcast that gave the “misleading impression” that Anktiva, the company’s treatment for a type of bladder cancer, can cure or prevent all cancers. The ad …
GitHub ‘OpenClaw Deployer’ Repo Delivers Trojan Instead
An AI-assisted campaign is spreading more than 300 poisoned packages for diverse assets ranging from developer tools to game cheats.
Determinants and Health Outcomes of Digital Health Literacy in Patients With Cardiovascular Disease: Systematic Review and Meta-Analysis
Background: With expansion of technology-enabled care, digital health literacy (DHL) has become integral to effective cardiovascular disease (CVD) management. However, quantitative evidence regarding determinants and health outcomes of DHL in CVD remains limited and heterogeneous, necessitating comprehensive evidence synthesis. Objective: This study aimed to (1) estimate DHL levels, (2) synthesize DHL-associated factors, and (3) examine […]
Karyopharm eyes Xpovio filing in myelofibrosis on mixed data
Despite hitting just one of two efficacy endpoints in a pivotal trial, Karyopharm thinks it still has a path to approval for Xpovio in myelofibrosis.
Can the UK end animal testing sooner? MHRA unveils new support for alternatives
The UK’s medicines regulator is backing developers using non‑animal methods, offering early data reviews to help phase out animal testing while keeping medicines safe and effective The Medicines and Healthcare products Regulatory Agency (MHRA) is taking major steps to accelerate the phasing out of animal testing in drug development and research. With early regulatory reviews […]
The Impact of Evaluation Strategy on Sepsis Prediction Model Performance Metrics in Intensive Care Data: Retrospective Cohort Study
Background: The prediction of the onset of sepsis, a life-threatening condition resulting from a dysregulated response to an infection, is one of the most common prediction tasks in intensive care–related machine learning research. To assess the performance of such models, different evaluation strategies, including fixed horizon (a single prediction at a set time before onset), […]
Karyopharm’s mixed myelofibrosis data; Rezolute to seek FDA approval despite trial failure
Plus, news about Aardvark Therapeutics, RA Capital, Gilead and EpiFrontier: 📊 Karyopharm’s late-phase myelofibrosis data: The company’s drug selinexor achieved one co-primary endpoint but missed on the other in a …
Q&A: Controversial embryo editing entrepreneur Cathy Tie on her new startup
Cathy Tie has an audacity more typical of a tech startup founder than a biotech executive. She dropped out of college to start a genetic screening company and later founded a telemedicine startup. The 29-year-old …
MSD taps Quotient for IBD drug targets in $2.2bn deal
MSD is paying $20m upfront to activate an alliance with Flagship’s Quotient Therapeutics to find new targets in inflammatory bowel disease.