YWHAG Syndrome (Developmental and Epileptic Encephalopathy 56, DEE56) is an ultra- rare childhood epilepsy associated with neurodevelopmental delays, with no therapeutic intervention available. Multiple de novo mutations in the YWHAG gene, encoding for the 14-3-3gamma protein, have been identified as causative for YWHAG Syndrome. 14-3-3gamma interacts with various targets, including major neurodevelopmental signaling proteins such […]
Automated Detection of Macro-Reentrant Atrial Tachycardia Circuits Using LAT-Derived Graph Networks
Background: Accurate identification of macro-reentrant atrial tachycardia (AT) circuits is critical for successful ablation but remains challenging with conventional mapping techniques. The aim of this study was to automatically detect macro-reentrant AT loops from high-density local activation time (LAT) maps. Methods: We developed an algorithm for automated detection of macro-reentrant AT circuits using LAT-derived directed […]
Prefrontal Mechanisms of Rule Learning
Rule learning is associated with lasting changes in prefrontal activity. However, experiments typically focus on learning a single set of rules or task, and there remains a significant gap regarding how related mechanisms may reflect behavioral improvements in different contexts, especially when examining across different tasks and modalities. We therefore recorded single units from chronic […]
Carsickness Therapy Based on Brain-Computer Interface Enhanced Mindfulness Meditation Training
Carsickness impairs comfort and affects a large proportion of the population. However, interventions that provide a therapeutic solution to carsickness have yet to be established. Here we introduce a wearable mindfulness meditation brain-computer interface (MM-BCI) system as a closed-loop training therapy for carsickness. The system records electroencephalographic activity, decodes meditative state in real time and […]
Basic Region Variants of the MAX b-HLH-LZ preferentially form heterodimers with the MYC b-HLH-LZ to bind the E-box, rather than binding as homodimers.
The MYC associated factor X (MAX) is the heterodimeric partner of the MYC paralogs (MYC, MYCN and MYCL). When deregulated, high level of the MYC paralogs contribute to all aspects of tumorigenesis and tumor growth. MAX can also heterodimerize with the MXD proteins, MNT and MGA. Heterodimerization and sequence specific DNA binding to the E-Box […]
A Protocol for Identifying Priorities for Women+ Health in the Maritime Provinces using a Priority Setting Partnership Approach
Background/Objectives: Women+ (e.g., women and individuals assigned female at birth) experience disproportionate health risks and persistent gaps in access to care, despite regionally coordinated health systems. Women+ health research remains significantly underfunded and understudied, contributing to inequities in diagnosis, treatment, and outcomes. This study aims to collaboratively identify and prioritize the most pressing unanswered research […]
A Tissue Virus Microenvironment with Activated Stress Responses Underlies Durable SIV Persistence
HIV persistence during suppressive antiretroviral therapy (ART) remains a central barrier to cure, with the majority of reservoirs residing in gut-associated lymphoid tissues (GALT). Here, we define a spatially organized viral microenvironment (VME) that sustains reservoir durability and governs early viral rebound by comparing animals initiating ART early after infection (transient reservoirs) versus late (persistent […]
Consistency of Serial CSF alpha-Synuclein Seed Amplification Assay Results in the Parkinson’s Progression Marker Initiative
Studies reporting alpha-synuclein seed amplification assay (aSyn-SAA) results are often cross-sectional. Here we investigated the intra-individual consistency of aSyn-SAA results over time from participants in the Parkinson’s Progression Marker Initiative (PPMI). A total of 1238 participants had >1 CSF aSyn-SAA result for analysis (Parkinson’s disease [PD]=633, prodromal =563, healthy control [HC]=42) which were collected over […]
Developmental Correlates of Epigenetic and Polygenic Indices of Cognition and Educational Attainment from Birth to Young Adulthood
Large-scale genomic studies have identified biomarkers of adult cognitive functioning and educational attainment, yet the developmental pathways connecting these biomarkers to adult outcomes remain unclear. Drawing on four cohorts, we examined the developmental correlates of an epigenetic index of adult cognitive function ("Epigenetic-g") alongside polygenic indices of cognition and education. Epigenetic-g and polygenic indices were […]
Instantaneous Wave-Free Ratio-Guided vs Angiography-Guided Coronary Artery Bypass Grafting: 36-Months Graft Patency and Clinical Outcomes of a Randomized Trial
Background: Coronary artery bypass grafting (CABG) to physiologically non-significant coronary artery stenosis may result in graft failure due to competitive native flow. We evaluated whether an instantaneous wave-free ratio (iFR)-guided revascularization strategy improves graft patency and clinical outcomes compared to conventional angiography-guided CABG. Methods: In this prospective, randomized, single-blinded trial, patients with multivessel disease and […]
A critical role of epithelial MHCII in initiation of autoimmune tumorigenesis and sustaining premalignancy growth in the stomach
Autoimmunity is emerging as a new etiology for early-onset gastric cancer (GC). However, it remains unclear what molecular pathways drive the initiation and progression of autoimmune tumorigenesis. Given that Major Histocompatibility Complex Class II (MHCII) is the strongest genetic risk factor for many autoimmune diseases, we hypothesized that MHCII-mediated autoantigen presentation drives tumorigenic differentiation of […]
Routine Data for Workforce Equality Monitoring: Ethnic Inequalities in Recruitment and Workforce Representation in Nursing and Midwifery
Aim To examine ethnic inequalities in recruitment outcomes and workforce representation across pay bands among nursing and midwifery staff, and to assess whether routinely collected administrative data can generate reproducible indicators for workforce equality monitoring. Design Retrospective observational study. Methods We analyzed routinely collected administrative data from one NHS Board in Scotland. This included annual […]