ObjectivesThe transition from paper medical records to electronic health records (EHRs) has enabled the extraction of substantial real-world data, which can support future real-world evidence generation. This study aimed to convert heterogeneous oncology data from local EHR systems—collectively referred to as COMNet—into a standardized data model. In particular, the Observational Medical Outcomes Partnership Common Data […]
A randomized, unblinded, controlled clinical study to assess the mobile digital health application INKA in the management of therapy refractory overactive bladder and mixed incontinence
BackgroundThis exploratory, two-arm, randomized, unblinded, controlled, multicentre study assessed the health benefits of the INKA app, a MDR class I CE-marked digital therapy companion for patients with overactive bladder (OAB) and mixed incontinence (MI). INKA offers self-guided educational, behavioural, and motivational content, along with physiotherapy modules and supports daily self-management, in accordance with current clinical […]
Editorial: Advancing vocal biomarkers and voice AI in healthcare: multidisciplinary focus on responsible and effective development and use
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Digital rehabilitation in a low-resource setting: lessons from building an integrated ecosystem in Burundi
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Creating customized chatbots with ChatGPT to promote physical activity: a mini review
Artificial intelligence (AI) chatbots powered by large language models (LLMs) such as ChatGPT offer a promising approach for delivering scalable, personalized physical activity interventions. Despite growing interest in applying these tools to health behaviour change, concerns remain regarding accuracy, safety, hallucinations, privacy, and theoretical grounding. This mini-review summarizes current methods for creating customized ChatGPT-based chatbots […]
Assessing nurses’ attitudes toward artificial intelligence in Kazakhstan: psychometric validation of a nine-item scale
BackgroundArtificial intelligence (AI) is increasingly integrated into healthcare, yet the attitudes and knowledge of nurses, who are the key mediators of AI implementation, remain underexplored. This study aimed to evaluate the psychometric properties of a previously validated nine-item scale measuring nurses’ knowledge and attitudes toward AI and to describe preliminary findings from primary healthcare centre […]
Bioethical considerations in deploying mobile mental health apps in LMIC settings: insights from the MITHRA pilot study in rural India
IntroductionIn India, untreated depression among women contributes significantly to morbidity and mortality, underscoring an urgent need for accessible and ethically grounded mental health interventions. Mobile health (mHealth) tools offer scalable solutions; however, their implementation in low- and middle-income country (LMIC) settings raises important bioethical considerations.MethodsThis study was conducted at the conclusion of a pilot randomized […]
Measuring and reducing surgical staff stress in a realistic operating room setting using EDA monitoring and smart hearing protection
BackgroundStress is a critical factor in the operating room (OR) and affects both the performance and well-being of surgical staff. Measuring and mitigating this stress can therefore improve patient safety and healthcare worker health.ObjectiveThis study aimed to evaluate the stress levels of OR staff in a simulated surgical setting using electrodermal activity (EDA) and to […]
Dysregulation of Hippo Signaling Pathway as a Convergent Mechanism Underlying Choroid Plexus Defects in Bipolar Disorder
Bipolar disorder (BD) is a prevalent and highly heritable psychiatric condition. Developmental mechanisms are implicated but the specific molecular origins remain unclear. The choroid plexus (ChP), which regulates cerebrospinal fluid (CSF) and brain homeostasis, has been implicated in BD, but its role is poorly understood. Here, we identify aberrant expansion of ChP in human cortical […]
Pinus sp. leaf extracts exert antileishmanial effects against Leishmania donovani by targeting trypanothione reductase
The urgent need for new antileishmanial drugs with novel mechanisms of action is driven by the limited efficacy, high toxicity, and growing resistance to currently available treatments. This study investigates the antileishmanial potential of extracts from Pinus sp., a plant widely used in the Cameroonian pharmacopoeia to treat various infections, including cough and fever conditions. […]
Structural Basis of Mitochondrial Transcription Regulation via Interactions of PolRMT and TFAM with Upstream Promoter DNA
Mitochondrial DNA (mtDNA) transcription is essential for cellular energy production and is carried out by a streamlined transcription system in which transcription factor A (TFAM), transcription factor B2 (TFB2M), and the mitochondrial RNA polymerase (PolRMT) assemble at defined promoters to initiate transcription. Previous structural studies elucidated the core initiation mechanism but relied on truncated promoter […]
Pinus sp. leaf extracts exert antileishmanial effects against Leishmania donovani by targeting trypanothione reductase
The urgent need for new antileishmanial drugs with novel mechanisms of action is driven by the limited efficacy, high toxicity, and growing resistance to currently available treatments. This study investigates the antileishmanial potential of extracts from Pinus sp., a plant widely used in the Cameroonian pharmacopoeia to treat various infections, including cough and fever conditions. […]