A trio of scientists behind the first gene therapy approved in the United States have been awarded a Breakthrough Prize in Life Sciences. It’s arguably one of the most prominent recognitions yet for the field …
RevMed’s stunning success; FDA to reclassify peptides; and more
Welcome back to Endpoints Weekly! Q1 earnings season is officially upon us. Max Gelman kicked off our coverage this week with a story about Johnson & Johnson’s confidence in navigating biosimilar competition …
Bias, representation, and clinical fidelity in AI-generated images for medical education: a systematic literature review
npj Digital Medicine, Published online: 18 April 2026; doi:10.1038/s41746-026-02608-3 Bias, representation, and clinical fidelity in AI-generated images for medical education: a systematic literature review
A scoping review of the characteristics, responsibilities, implementations and evaluations of digital navigators in healthcare
npj Digital Medicine, Published online: 18 April 2026; doi:10.1038/s41746-026-02647-w A scoping review of the characteristics, responsibilities, implementations and evaluations of digital navigators in healthcare
Development and prospective shadow evaluation of a domain-specific large language model for emergency neurological diagnosis
npj Digital Medicine, Published online: 18 April 2026; doi:10.1038/s41746-026-02644-z Development and prospective shadow evaluation of a domain-specific large language model for emergency neurological diagnosis
Predictive models for the occurrence and lymph node metastasis of papillary thyroid carcinoma with regional risk heterogeneity
npj Digital Medicine, Published online: 18 April 2026; doi:10.1038/s41746-026-02649-8 Predictive models for the occurrence and lymph node metastasis of papillary thyroid carcinoma with regional risk heterogeneity
AI Augmented Confocal Laser Endomicroscopy for Rapid Intraoperative Diagnosis of Brain Tumors
npj Digital Medicine, Published online: 18 April 2026; doi:10.1038/s41746-026-02651-0 AI Augmented Confocal Laser Endomicroscopy for Rapid Intraoperative Diagnosis of Brain Tumors
Phosphoregulated SMCR8-FIP200 interaction connects the ALS/FTD-linked C9orf72 complex to autophagy initiation and mitochondrial quality control
Hexanucleotide (GGGGCC) repeat expansions in the non-coding region of C9ORF72 are a major genetic cause of ALS/FTD and reduce C9orf72-SMCR8-WDR41 complex levels, but how this contributes to autophagy-lysosome dysfunction and previously reported mitochondrial quality-control defects in C9ORF72-ALS/FTD remains unclear. Here we identify a direct interaction between SMCR8 and the FIP200 subunit of the ULK1/2 autophagy […]
Therapy-associated mutagenesis at CTCF binding sites is shaped by chromatin context and DNA repair capacity
Genotoxic cancer therapies introduce DNA damage that can be fixed as somatic mutations in surviving tumor cells. However, the impact of therapy-associated mutagenesis on regulatory elements remains unclear. CTCF binding sites (CBS) are chromatin architectural elements that exhibit recurrent localized mutation enrichment in cancer genomes. We asked whether treatment exposure is associated with increased mutagenesis […]
Dissecting polycomb complexes for enhanced fetal hemoglobin production
Polycomb repressive complexes PRC1 and PRC2 regulate diverse developmental processes, including the fetal-to-adult switch in hemoglobin production, a process whose reversal is a goal for the treatment of sickle cell disease and beta-thalassemia. PRC inhibitors show promise for various disorders, but use is limited because of pleiotropic PRC activities. We explored whether fetal hemoglobin (HbF) […]
Dissecting polycomb complexes for enhanced fetal hemoglobin production
Polycomb repressive complexes PRC1 and PRC2 regulate diverse developmental processes, including the fetal-to-adult switch in hemoglobin production, a process whose reversal is a goal for the treatment of sickle cell disease and beta-thalassemia. PRC inhibitors show promise for various disorders, but use is limited because of pleiotropic PRC activities. We explored whether fetal hemoglobin (HbF) […]
Therapy-associated mutagenesis at CTCF binding sites is shaped by chromatin context and DNA repair capacity
Genotoxic cancer therapies introduce DNA damage that can be fixed as somatic mutations in surviving tumor cells. However, the impact of therapy-associated mutagenesis on regulatory elements remains unclear. CTCF binding sites (CBS) are chromatin architectural elements that exhibit recurrent localized mutation enrichment in cancer genomes. We asked whether treatment exposure is associated with increased mutagenesis […]