Formation of the beta-amyloid (Abeta) plaques is a pathological hallmark of Alzheimer’ s disease (AD), and is believed to be a primary cause of dementia in elderly individuals. In the present work, we simulated the conformational evolution of Abeta42 dimers in solution and in membrane-like environment to explore the folding of Abeta42 along fibrillation. The […]
The Origin and Migration of the Ameru Community in Kenya based on mtDNA analysis.
Human diversity did not only remain restricted to their socio-cultural and linguistic domains but also have penetrated deep inside their genetic root. Africa harbors more genetic diversity than any other part of the world. Diversification of the African lineages were complex, involving long-distance gene flow. Data from Africansis needed to better understand the origin and […]
Modular Deep Learning for Direct RNA Sequence Design via Self-Contained RNA Units
RNA sequence design is a pivotal challenge in synthetic biology, yet state-of-the-art deep learning methods face a fundamental bottleneck: the scarcity of high-resolution 3D structures. To compensate for limited training data, existing approaches like NA-MPNN and RiboDiffusion employ computationally expensive autoregressive or iterative diffusion sampling, substantially limiting their throughput and scalability. In this work, we […]
Pauses in a fast-paced life: Intermittent hovering in hummingbirds
Hummingbirds are known for sustained hovering powered by rapid and continuous wingbeats. Here, we describe and quantify a novel flight behavior, intermittent hovering, in which hovering hummingbirds momentarily pause their wing motion mid-air but maintain their vertical position in space, keeping their wings fully extended at the end of the upstroke. We present the first […]
Mapping breast cancer lineage in radiation and immunotherapy using the REMAP mouse
We present REMAP (Recording Evolution in Mammary tumors via Active PyMT), a lineage-tracing mouse model that integrates inducible CRISPR recording with the MMTV-PyMT model of hormone receptor-positive (HR+) breast cancer. Inducible Cas9 drives editing of MARC1 homing guide RNAs (hgRNAs), generating heritable lineage marks, and enables reconstruction of clonal relationships. Using REMAP, we profiled tumor […]
Assessing the impact of artificial night lighting regulations designed to protect astronomical observatories on seabirds and bats
Artificial light at night is a rapidly increasing driver of global change, affecting both astronomical observations and biodiversity. Regulations such as the Canary Islands’ "Sky Law" were designed to protect astronomical observations by controlling light intensity and spectral composition, yet their ecological effectiveness remains largely untested. Here, we experimentally assessed whether lighting conditions permitted under […]
Characterization of six environmental coli-phages isolated in Astana, Kazakhstan, during the School of Molecular and Theoretical Biology
Bacteriophage (phage) collections are essential resources for studying virus-host interactions in bacterial species. Here, we report six Escherichia coli-infecting phages that expand the Lund Collection of Bacteriophages. These phages were isolated in 2025 within the framework of the School of Molecular and Theoretical Biology for high-school students, from samples collected in Lake Taldykol, Astana, Kazakhstan, […]
Energetic misfires: Hybridization drives transgressive expression in metabolic pathways in thermally divergent Icelandic stickleback
Climate change is causing rapid changes to freshwater environments, driving selection for phenotypes that can cope with altered thermal conditions, while also changing developmental environments. This may promote local adaptation, migration to new habitats, and/or phenotypic plasticity. Climate change may also increase hybridization rates between locally adapted phenotypes, as populations migrate and spatially mix in […]
Testing fundamental hypotheses of colonization success in the ferns
Background and Aims. Non-native species are now ubiquitous members of regional floras. The factors that lead to establishment and dominance of non-native species are continuously debated. Fundamental hypotheses about drivers of invasion success include the role of phylogeny, polyploidy, genome size, and rapid niche evolution. These hypotheses have been tested in the seed plants, but […]
Beyond Level-1: Fast Inference of Generic Semi-directed Phylogenetic Networks
Phylogenetic networks capture reticulate evolution, but existing methods have mostly been restricted to level-1 topologies. This restriction severely limits the biological applicability of phylogenetic network inference. Here, we extend the widely used SNaQ method to scalably infer arbitrary binary, metric, semi-directed phylogenetic networks while allowing optional restriction to a user-specified network space. We implement computational […]
Attentive-SPIDNA: Attention-based neural networks for population genetics
Artificial neural networks (ANNs) have recently offered new perspectives to solve inference problems from high dimensional data in numerous scientific fields, but it is yet unclear which architectures are the most suited to genomic data. Here, we present a new ANN architecture integrating attention mechanisms to infer effective population size history from genomic data. Built […]
Frequent seasonal reassortment between high and low path viruses drives the diversification of influenza A/H5N1
Since 2021, highly pathogenic (HPAI) H5N1 viruses have spread across the Americas, diversifying via reassortment into new genotypes that have spilled into humans and livestock, raising fears of a new influenza pandemic. Pandemic lineages are typically associated with reassortment, but we currently have limited understanding of where and when reassortment is expected to occur, which […]