An interpretable, clinically grounded framework for digital speech biomarker development in neurodegenerative diseases

IntroductionCommunication ability—a key determinant of quality of life—is frequently affected and progressively declines in neurodegenerative diseases. Effective management of progressive communication disorders requires a personalized approach to deliver timely interventions tailored to the evolving profiles of communicative impairment, thereby supporting functional communication throughout the disease course. To this end, reliable tools capable of detecting and […]

Assessment of frontier Large Language Models in sleep medicine

Study objectivesTo evaluate and compare the performance of two proprietary frontier large language models (LLMs), ChatGPT-5 and Grok-4, on diagnostic reasoning and foundational knowledge tasks within the specialty domain of sleep medicine.MethodsThe models were evaluated on two tasks: case-based reasoning using 79 clinical vignettes from the AASM Case Book of Sleep Medicine and knowledge assessment […]

Film-based cultural narrative intervention to enhance mental health literacy and resilience in indigenous adolescents: a mixed-methods co-design study

BackgroundIndigenous adolescents in low- and middle-income countries experience heightened mental health risks while having limited access to culturally appropriate interventions. Mental health literacy, stigma, and resilience are critical determinants of help-seeking and long-term well-being, yet culturally grounded interventions addressing these factors remain scarce.ObjectiveThis study aimed to co-design and evaluate a culturally sensitive, film-based intervention to […]

Behavior change beyond intervention: an activity-theoretical perspective on human-centered design of personal health technology

IntroductionModern personal technologies, such as smartphone apps with artificial intelligence (AI) capabilities, have a significant potential for helping people make necessary changes in their behavior (e.g., adopt healthier lifestyles). Current research highlights that realizing this potential through the design and use of personal technologies calls for a critical reappraisal of the role of healthcare interventions […]

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