Mutations are often thought to destabilize protein structures. However, many proteins are naturally unstructured and the effect of mutations on such proteins especially in the absence of selection, remains unclear. Here, we develop a computational model to study the effects of mutations on structural disorder in both random and natural sequences, including those derived from […]

Tomato (Solanum lycopersicum) is one of the most important agricultural crops and serves as a model system for fleshy fruit biology. However, domestication bottlenecks have led to limited genetic diversity for further crop improvement. Wild relatives represent a rich reservoir of phenotypic diversity, yet the molecular basis underlying such phenotypic diversity remains largely unknown. As […]

Determining the environmental limits that govern how engineered metabolic traits control whole-plant carbon (C) allocation is essential for developing climate-resilient bioenergy systems. Oil-enhanced sorghum offers a promising strategy to boost aboveground energy density, yet its system-wide effects on root C investment and soil C delivery, particularly under drought, are largely uncharacterized. Here, we provide the […]

Migratory seabirds are valuable indicators of marine ecosystem change but can be difficult to monitor during the breeding season due to dense colonies, remote breeding sites, and sensitivity to investigator disturbance. Passive acoustic monitoring offers a minimally invasive alternative to traditional surveys; however, high call overlap in large colonies complicates approaches that rely on identifying […]

Epigenetic regulation, particularly histone acetylation, plays a critical role in skeletal muscle differentiation by modulating gene expression programs without altering DNA sequence. Histone deacetylases (HDACs) tightly regulate myogenesis by controlling the timing of differentiation. Pharmacological inhibition of HDACs has shown context-dependent effects on muscle cells. We investigated the effects of 1 uM SAHA (suberoylanilide hydroxamic […]

Coastal wetlands of the Laurentian Great Lakes support abundant populations of fish, invertebrates, and vegetation, though the trophic linkages connecting primary production and lower consumers is not well understood in these systems. We implemented a multiple-tracer approach to evaluate trophic pathways, pairing traditional food web isotope tracers like carbon (delta13C) and nitrogen (delta15N) with total […]

Wildfire regimes in Mediterranean landscapes are undergoing significant changes due to the combined effects of land-use transitions and climate change. In particular, land abandonment increased fuel availability, the expansion of the wildland urban interface increased ignition frequency, while climate change increases the chances of fire-weather conditions and reduces vegetation recovery capacity. This study presents a […]