The hippocampus and medial prefrontal cortex (mPFC) are required for delayed working-memory tasks, but when in the task their engagement becomes necessary remains an open question. We trained mice on a delayed cue-guided T-maze navigation task and used transient optogenetic silencing to test the contribution of the mPFC and hippocampus during distinct task epochs. Surprisingly, […]

Adult neurogenesis in the olfactory bulb (OB) contributes to structural and functional plasticity, influencing olfactory perception, learning, and memory. Adult-born granule cells (abGCs) exhibit unique morphological, electrophysiological, and synaptic properties compared to their neonatally born counterparts, suggesting a specialized role in olfactory processing. In the OB, such processing relies both on sensory inputs from the […]

Chronic stress induces structural and functional changes in the brain, increasing susceptibility to major depressive disorder and other mental illnesses. Myelination deficits are a key pathological feature of stress-related disorders, yet the molecular mechanisms linking chronic stress to oligodendrocyte dysfunction remain poorly understood. Here, we used single-nucleus multiome sequencing to map gene expression and chromatin-accessibility […]

Hemodynamic lag in white matter (WM) remains poorly understood despite its relevance to neurovascular health. We developed Local Propagation Mapping to quantify the spatiotemporal architecture of relative hemodynamic timing within WM. In young adults, WM lag architecture was reliable, aligned with venous anatomy, and reconfigured during working-memory task engagement; the magnitude of macroscopic lag modulation […]

For the brain to compute, electrical signals must propagate over the membranes of individual neurons, connecting synaptic inputs to synaptic outputs. Complex neuronal morphologies coupled with the spatial organization of synaptic inputs and outputs enable diverse voltage transformations that underlie cell-type specific computations. However, measuring these transformations in vivo has remained challenging, leaving a crucial […]

Phylogenetic comparative methods are a critical tool in biology, providing the framework to test evolutionary hypotheses of phenotypic diversification. Accommodating intraspecific variation in these analyses is critical for accurate evolutionary inference, but current multivariate methods either assume traits evolve independently or that all taxa share the same intraspecific covariance structure. Violations of these assumptions can […]