Regions within ventral occipito-temporal cortex exhibit category-selective BOLD responses during episodic encoding and retrieval of visual information. How these regions interact with other brain areas during successful encoding and retrieval, and whether these interactions relate to memory performance, remains unclear. The present study examined category-selective functional connectivity using psychophysiological interaction (PPI) analyses in younger and […]
Early reaction time variability predicts implicit statistical learning: a comparison of four variability indices
High intra-individual reaction time variability (RTV) is traditionally viewed through a deficit perspective and interpreted as a maladaptive signature of attentional lapses, cognitive inefficiency, and systemic noise. However, theories from motor learning and the competitive neurocognitive networks framework suggest that behavioral variability and reduced top-down control might actually facilitate certain forms of implicit skill acquisition. […]
Optical genome mapping identifies source-associated structural variant differences across early-passage human iPSCs
Background: Induced pluripotent stem cells (iPSCs) are an important model for studying human diseases in vitro. However, previous studies have shown that iPSC reprogramming and extended cell culture can introduce genomic structural variants (SVs). Technologies like karyotyping, CNV microarrays, and whole-genome sequencing have limitations in resolution, sensitivity, or the ability to detect large and complex […]
Neural birth time and somatosensory circuit assembly are linked by Robo3 regulation of dendrite morphology
Neural circuit wiring requires a remarkable level of precision, as thousands of neurons generate millions of synapses in distinct configurations. While neural circuits are known to be shaped by both neural birth timing and multiple classes of guidance molecules, the relationship between the two and how they coordinate circuit assembly has yet to be evaluated. […]
Paraventricular thalamus gates hippocampal coding of salient experiences.
Adaptive behavior requires neural circuits that encode salient stimuli to guide approach and avoidance. The hippocampal ventral subiculum (vSub) encodes information related to avoidance and reward seeking, yet how upstream inputs shape its representations of salient appetitive and aversive events remains unclear. Here, we show that a projection from the anterior paraventricular thalamus (PVT) to […]
Automated analysis of feeding dynamics from electromyographic recordings in a blood-sucking insect
Feeding behavior in blood-sucking insects relies on gustatory evaluation to decide on sustained ingestion, yet quantifying this process from electromyogram (EMG) recordings is labor-intensive. Here we developed MyoRec, an automated computational framework employing machine learning to analyse EMG signals from the triatomine bug Rhodnius prolixus. Using recordings under appetitive and aversive conditions, a convolutional neural […]
Automated analysis of feeding dynamics from electromyographic recordings in a blood-sucking insect
Feeding behavior in blood-sucking insects relies on gustatory evaluation to decide on sustained ingestion, yet quantifying this process from electromyogram (EMG) recordings is labor-intensive. Here we developed MyoRec, an automated computational framework employing machine learning to analyse EMG signals from the triatomine bug Rhodnius prolixus. Using recordings under appetitive and aversive conditions, a convolutional neural […]
Paraventricular thalamus gates hippocampal coding of salient experiences.
Adaptive behavior requires neural circuits that encode salient stimuli to guide approach and avoidance. The hippocampal ventral subiculum (vSub) encodes information related to avoidance and reward seeking, yet how upstream inputs shape its representations of salient appetitive and aversive events remains unclear. Here, we show that a projection from the anterior paraventricular thalamus (PVT) to […]
Neural birth time and somatosensory circuit assembly are linked by Robo3 regulation of dendrite morphology
Neural circuit wiring requires a remarkable level of precision, as thousands of neurons generate millions of synapses in distinct configurations. While neural circuits are known to be shaped by both neural birth timing and multiple classes of guidance molecules, the relationship between the two and how they coordinate circuit assembly has yet to be evaluated. […]
Optical genome mapping identifies source-associated structural variant differences across early-passage human iPSCs
Background: Induced pluripotent stem cells (iPSCs) are an important model for studying human diseases in vitro. However, previous studies have shown that iPSC reprogramming and extended cell culture can introduce genomic structural variants (SVs). Technologies like karyotyping, CNV microarrays, and whole-genome sequencing have limitations in resolution, sensitivity, or the ability to detect large and complex […]
Developmental genetic response of the zooplanktonic tunicate Oikopleura dioica to marine noise pollution.
Background: Anthropogenic noise is an emerging threat to marine ecosystems, yet its effects on marine invertebrates, particularly zooplanktonic species, remain poorly understood. Despite increasing evidence of behavioral and physiological impacts in invertebrates, the effects of noise on embryonic development and the molecular mechanisms underlying acoustic responses remain largely unexplored. Here, to address this gap, we […]
Modes of natural selection on maternal and zygotic gene expression in Drosophila melanogaster embryos
Early embryonic development involves the coordination of gene expression from two distinct genomes, as mothers load eggs with gene products prior to the beginning of zygotic transcription. Because the maternal transcriptome is controlled by the mothers regulatory genotype rather than that of the embryo, these two sequential developmental programs may experience distinct evolutionary constraints and […]