Digital health tools are generally poorly regulated and often lack strong research evidence, posing challenges for purchasers of point solutions such as employer groups and insurers. Point solutions, which are digital tools designed to manage health-related conditions, to promote wellness, and/or to drive member engagement, present unique challenges for purchasers. In this Review we provide […]
From Engel’s Bio-Psycho-Social model to the personalized health determinants model: a comprehensive framework and illustrative operationalization for precision health
Engel’s Bio-Psycho-Social (BPS) model (1977) reframed healthcare by integrating biological, psychological, and social perspectives. Despite its influence, the model has been criticized for insufficient specificity in domains critical to precision health, including nutrition, lifestyle, socioeconomic, environmental, and structural factors. To address these limitations, we propose the Personalized Health Determinants Model (PHDm), a comprehensive nine-dimension framework, […]
ActiTect: a generalizable machine learning pipeline for REM sleep behavior disorder screening through standardized actigraphy
npj Digital Medicine, Published online: 13 June 2026; doi:10.1038/s41746-026-02738-8 ActiTect: a generalizable machine learning pipeline for REM sleep behavior disorder screening through standardized actigraphy
Lipid Flippase Mediated Membrane Asymmetry Governs Extracellular Vesicles Biogenesis and Host Interactions in Cryptococcus neoformans
Cryptococcus neoformans is the leading cause of fungal meningitis in immunocompromised patients. Alveolar macrophages are the first line of defense against Cryptococcus infection. Our previous study showed that deletion of Cdc50, the regulatory subunit of P4-ATPase (lipid flippase) complex, results in increased phagocytosis and macrophage killing, and avirulence in animal models. However, how fungal flippase […]
Projected population level impact and cost-effectiveness of clinic and community-based tuberculosis screening approaches
The South Africa National Department of Health have set ambitious targets to scale up TB testing, focusing primarily on clinic attendees. In the context of declining funding for TB care and prevention, the most cost-effective approaches for targeting testing should be identified. We developed a mathematical model of TB in South Africa, explicitly incorporating clinic […]
Reassessing the evidence linking clinical leadership to AI deployment outcomes
npj Digital Medicine, Published online: 13 June 2026; doi:10.1038/s41746-026-02911-z Reassessing the evidence linking clinical leadership to AI deployment outcomes
ActiTect: a generalizable machine learning pipeline for REM sleep behavior disorder screening through standardized actigraphy
npj Digital Medicine, Published online: 13 June 2026; doi:10.1038/s41746-026-02738-8 ActiTect: a generalizable machine learning pipeline for REM sleep behavior disorder screening through standardized actigraphy