The npj Digital Medicine Editorial Fellowship

npj Digital Medicine, Published online: 03 November 2025; doi:10.1038/s41746-025-02136-6 The npj Digital Medicine Editorial Fellowship ( https://www.nature.com/npjdigitalmed/editorial-fellowship ) is a year-long program that provides trainees

  • Home
  • DTx
  • Generative AI in clinical (2020–2025): a mini-review of applications, emerging trends, and clinical challenges

Generative AI in clinical (2020–2025): a mini-review of applications, emerging trends, and clinical challenges

Generative artificial intelligence (G-AI) has moved from proof-of-concept demonstrations to practical tools that augment radiology, dermatology, genetics, drug discovery, and electronic-health-record analysis. This mini-review synthesizes fifteen studies published between 2020 and 2025 that collectively illustrate three dominant trends: data augmentation for imbalanced or privacy-restricted datasets, automation of expert-intensive tasks such as radiology reporting, and generation of new biomedical knowledge ranging from molecular scaffolds to fairness insights. Image-centric work still dominates, with GANs, diffusion models, and Vision-Language Models expanding limited datasets and accelerating diagnosis. Yet narrative (EHR) and molecular design domains are rapidly catching up. Despite demonstrated accuracy gains, recurring challenges persist: synthetic samples may overlook rare pathologies, large multimodal systems can hallucinate clinical facts, and demographic biases can be amplified. Robust validation, interpretability techniques, and governance frameworks therefore, remain essential before G-AI can be safely embedded in routine care.

Subscribe for Updates

Copyright 2025 dijee Intelligence Ltd.   dijee Intelligence Ltd. is a private limited company registered in England and Wales at Media House, Sopers Road, Cuffley, Hertfordshire, EN6 4RY, UK registeration number 16808844