arXiv:2511.04047v1 Announce Type: new
Abstract: The reductionist approach commonly employed in scientific methods presupposes that both macro and micro phenomena can be explained by micro-level laws alone. This assumption implies intra-level causal closure, rendering all macro phenomena epiphenomenal. However, the integrative nature of consciousness suggests that it is a macro phenomenon. To ensure scientific testability and reject epiphenomenalism, the reductionist assumption of intra-level causal closure must be rejected. This implies that even neural-level behavior cannot be explained by observable neural-level laws alone. Therefore, a new methodology is necessary to acknowledge the causal efficacy of macro-level phenomena. We model the brain as operating under dual laws at different levels. This model includes hypothetical macro-level psychological laws that are not determined solely by micro-level neural laws, as well as the causal effects from macro to micro levels. In this study, we propose a constructive approach that explains both mental and physical phenomena through the interaction between these two sets of laws.
OptoLoop: An optogenetic tool to probe the functional role of genome organization
The genome folds inside the cell nucleus into hierarchical architectural features, such as chromatin loops and domains. If and how this genome organization influences the

