OptoLoop: An optogenetic tool to probe the functional role of genome organization

The genome folds inside the cell nucleus into hierarchical architectural features, such as chromatin loops and domains. If and how this genome organization influences the

Integrating Longitudinal Metabolite Profiles Improves Trait Prediction in Pigs in a Trait- and Timepoint-Dependent Manner

Background Accurate prediction of genetic merit is essential for accelerating genetic improvement in pigs, particularly for traits that are costly or difficult to measure directly.

A De Novo Algorithm for Allele Reconstruction from Oxford Nanopore Amplicon Reads, with Application to CYP2D6

The Oxford Nanopore Technologies’ sequencing platform offers a path towards bedside genomics, producing long reads that can completely cover a gene of interest, and thus

Efficacy of Minnelide in a Next-Generation Dual-Recombinase Regulated Genetically Engineered Mouse Model of CIC::DUX4 Sarcoma

CIC::DUX4 sarcoma (CDS) is a lethal cancer driven by a fusion between tumor suppressor Capicua (CIC) and pioneer transcription factor double homeobox 4 (DUX4). To

AI-assisted Image-Based Phenotyping Reveals Genetic Architecture of Pod Traits in Mungbean (Vigna radiata L.)

Mungbean (Vigna radiata (L.) R. Wilczek) is a vital source of digestible proteins and is well-suited for the plant-based protein industry. In this study, we

Wide-awake local anaesthesia no tourniquet hand surgery in Australia: an analysis of adoption, perceptions, and implementation in a global context

November 7, 2025

Background: Wide-awake local anaesthesia no tourniquet (WALANT) is increasingly used globally for hand surgery, offering clinical and operational benefits. However, its adoption in Australia remains understudied. This study assessed current WALANT usage among Australian hand surgeons to identify key factors influencing its implementation. Methods: A national cross-sectional survey of all Australian Hand Surgery Society (AHSS) active members (n 164) was conducted in 2024. The survey examined current WALANT use, perceived benefits and drawbacks, as well as facilitators and barriers of incorporation into practice. Quantitative data were analysed using descriptive and inferential statistics and qualitative data were analysed thematically. Results: Sixty-eight surgeons responded (41% response rate). Seventy percent had performed WALANT at least once, and 50% incorporated it in practice. Current WALANT use was associated with hand surgery fellowship (OR 8.7), prior WALANT exposure during training (OR 6.1), and practice in university/teaching hospital (OR 3.2). Respondents highlighted avoidance of general anaesthesia, shorter recovery, improved patient satisfaction, and lower costs as benefits. Conversely, workflow inefficiencies, limited outpatient infrastructure, concerns over anaesthetist scheduling and remuneration, and the absence of dedicated billing codes were the dominant barriers. Non-users viewed WALANT as more complex and remained wary of adrenaline safety, whereas users perceived more benefits and reported few technical concerns. Conclusion: WALANT is used by a substantial proportion of Australian hand surgeons, but broader adoption is limited by systemic and institutional barriers contributing to perception gap. Training, infrastructure, policy reform, appropriate funding mechanisms, and interprofessional collaboration may support wider integration of WALANT in Australia.

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