arXiv:2603.13294v3 Announce Type: replace-cross
Abstract: The rapid expansion of AI deployments has put organizational leaders in a decision maker’s dilemma: they must govern these technologies without systematic evidence of how systems behave in their own environments. Predominant evaluation methods generate scalable, abstract measures of model capabilities but smooth over the heterogeneity of real world use, while user focused testing reveals rich contextual detail yet remains small in scale and loosely coupled to the mechanisms that shape model behavior. The Forum for Real World AI Measurement and Evaluation (FRAME) addresses this gap by combining large scale trials of AI systems with structured observation of how they are used in context, the outcomes they generate, and how those outcomes arise. By tracing the path from an AI system’s output through its practical use and downstream effects, FRAME turns the heterogeneity of AI in use into a measurable signal rather than a trade off for achieving scale. FRAME establishes two core assets to accomplish this: a Testing Sandbox that captures AI use under real workflows at scale and a Metrics Hub that translates those traces into actionable indicators.
Three immunoregulatory signatures define non-productive HIV infection in CD4+ T memory stem cells
The persistent HIV reservoir constitutes the main obstacle to curing HIV/AIDS disease. Our understanding of how non-productive HIV infections are established in primary human CD4+



