arXiv:2604.04770v1 Announce Type: cross
Abstract: Balanced spiking networks can transition between silent, asynchronous-irregular, and oscillatory states depending on interacting synaptic and temporal time scales, while their joint parameter structure remains incompletely characterized. In this work, we systematically map how postsynaptic decay (taus), conduction delay (d), and plasticity rate (lambdap) jointly shape oscillatory regimes in recurrent leaky integrate-and-fire networks. By combining Brian2 simulations across the (taus, d, lambdap) space with a coarse Hopf-reference boundary, we construct regime maps that directly visualize SIL-AI-OSC transitions and corresponding spectral prominence landscapes. The mapped results show that increasing lambdap expands oscillatory regions toward shorter taus and moderate-to-long delays, while prominence maps identify parameter regions with the strongest rhythmic coherence. Representative control experiments further connect this global landscape to local rhythm-forming mechanisms, showing that STDP freezing weakens rhythmic coherence whereas delay jitter enhances it with minimal change in mean firing rate. As a result, these findings provide a useful reference for operating-point selection, synchrony modulation studies, and future biologically grounded spiking-network modeling within similar balanced-network settings.
Dysregulation of Hippo Signaling Pathway as a Convergent Mechanism Underlying Choroid Plexus Defects in Bipolar Disorder
Bipolar disorder (BD) is a prevalent and highly heritable psychiatric condition. Developmental mechanisms are implicated but the specific molecular origins remain unclear. The choroid plexus



