arXiv:2604.07558v1 Announce Type: cross
Abstract: Digital mental health (DMH) tools have extensively explored personalization of interventions to users’ needs and contexts. However, this personalization often targets what support is provided, not how it is experienced. Even well-matched content can fail when the interaction format misaligns with how someone can engage. We introduce generative experience as a paradigm for DMH support, where the intervention experience is composed at runtime. We instantiate this in GUIDE, a system that generates personalized intervention content and multimodal interaction structure through rubric-guided generation of modular components. In a preregistered study with N = 237 participants, GUIDE significantly reduced stress (p = .02) and improved the user experience (p = .04) compared to an LLM-based cognitive restructuring control. GUIDE also supported diverse forms of reflection and action through varied interaction flows, while revealing tensions around personalization across the interaction sequence. This work lays the foundation for interventions that dynamically shape how support is experienced and enacted in digital settings.
The Central Coupler of the AAA+ ATPase ClpXP Controls Intersubunit Communication and Couples the Conversion of Chemical Energy into the Generation of Force
ClpX is a clockwise hexameric helical arrangement that hydrolyzes ATP to unfold proteins and translocate them into the proteolytic chamber. We investigate the central coupler,

