arXiv:2604.07645v1 Announce Type: new
Abstract: The development of autonomous tool-use agents for complex, long-horizon tasks in collaboration with human users has become the frontier of agentic research. During multi-turn Human-AI interactions, the dynamic and uncertain nature of user demands poses a significant challenge; agents must not only invoke tools but also iteratively refine their understanding of user intent through effective communication. While recent advances in reinforcement learning offer a path to more capable tool-use agents, existing approaches require expensive training costs and struggle with turn-level credit assignment across extended interaction horizons. To this end, we introduce PRIME (Proactive Reasoning via Iterative Memory Evolution), a gradient-free learning framework that enables continuous agent evolvement through explicit experience accumulation rather than expensive parameter optimization. PRIME distills multi-turn interaction trajectories into structured, human-readable experiences organized across three semantic zones: successful strategies, failure patterns, and user preferences. These experiences evolve through meta-level operations and guide future agent behavior via retrieval-augmented generation. Our experiments across several diverse user-centric environments demonstrate that PRIME achieves competitive performance with gradient-based methods while offering cost-efficiency and interpretability. Together, PRIME presents a practical paradigm for building proactive, collaborative agents that learn from Human-AI interaction without the computational burden of gradient-based training.
What’s in a name? Moderna’s “vaccine” vs. “therapy” dilemma
Is it the Department of Defense or the Department of War? The Gulf of Mexico or the Gulf of America? A vaccine—or an “individualized neoantigen