arXiv:2512.01099v2 Announce Type: replace
Abstract: As modern artificial intelligence (AI) systems become more advanced and capable, they can leverage a wide range of tools and models to perform complex tasks. The task of orchestrating these models is increasingly performed by Large Language Models (LLMs) that rely on qualitative descriptions of models for decision-making. However, the descriptions provided to existing LLM-based orchestrators frequently do not reflect true model capabilities and performance characteristics, leading to suboptimal model selection, reduced task accuracy, and increased cost. In this paper, we conduct an empirical analysis of LLM-based orchestration limitations and propose a cost-aware model selection method that accounts for performance-cost trade-offs by incorporating quantitative model performance characteristics within decision-making. Initial experimental results demonstrate that our proposed method increases accuracy by 0.90%-11.92% across various evaluated tasks, achieves up to a 54% energy efficiency improvement, and reduces orchestrator model selection latency from 4.51 s to 7.2 ms.
Coordinated Temporal Dynamics of Glucocorticoid Receptor Binding and Chromatin Landscape Drive Transcriptional Regulation
Glucocorticoid receptor (GR) signaling elicits diverse transcriptional responses through dynamic and context-dependent interactions with chromatin. Here, we define a temporally resolved and mechanistically integrated framework


