arXiv:2502.04416v3 Announce Type: replace-cross
Abstract: Scaling large language models (LLMs) improves performance but significantly increases inference costs, with feed-forward networks (FFNs) consuming the majority of computational resources. While Mixture-of-Experts (MoE) architectures can reduce this cost through sparse activation, restructuring existing dense models into MoEs typically requires extensive retraining on hundreds of billions of tokens. We propose an analytical post-training framework that rapidly restructures FFNs into sparse MoE architectures using only a small calibration dataset. The method analyzes neuron activation patterns to partition neurons into always-active shared experts and conditionally activated routed experts, then constructs a router analytically from representative neuron statistics, enabling immediate deployment or optional lightweight fine-tuning. This approach applies both to dense models and recursively to existing MoE models for hierarchical sparsity. Experiments demonstrate up to $1.17times$ speedup in compute-bound scenarios with only minutes of processing and 2k-sample fine-tuning, outperforming methods requiring orders of magnitude more resources.
Coordinated Temporal Dynamics of Glucocorticoid Receptor Binding and Chromatin Landscape Drive Transcriptional Regulation
Glucocorticoid receptor (GR) signaling elicits diverse transcriptional responses through dynamic and context-dependent interactions with chromatin. Here, we define a temporally resolved and mechanistically integrated framework


