arXiv:2605.27967v1 Announce Type: cross
Abstract: Knowledge distillation is a powerful method for model compression, enabling the efficient deployment of complex deep learning models (teachers), including large language models. However, its underlying statistical mechanisms remain unclear, and uncertainty evaluation is often overlooked, especially in real-world scenarios requiring diverse teacher expertise. To address these challenges, we introduce textitMulti-Teacher Bayesian Knowledge Distillation (MT-BKD), where a distilled student model learns from multiple teachers within the Bayesian framework. Our approach leverages Bayesian inference to capture inherent uncertainty in the distillation process. We introduce a teacher-informed prior, integrating external knowledge from teacher models and task-specific training data, offering better generalization, robustness, and scalability. Additionally, an entropy-based weighting mechanism adaptively adjusts each teacher’s influence, allowing the student to combine multiple sources of expertise effectively. MT-BKD enhances the interpretability of the student model’s learning process, improves predictive accuracy, and provides uncertainty quantification. We validate MT-BKD on both synthetic and real-world tasks, including protein subcellular location prediction and image classification. Our experiments show improved performance and robust uncertainty quantification, highlighting the strengths of our MT-BKD framework.
Using GPT-4 to annotate the severity of all phenotypic abnormalities within the human phenotype ontology
IntroductionThe Human Phenotype Ontology (HPO) provides a unified framework cataloguing over 17,500 phenotypic abnormalities across more than 8,600 rare diseases, defining hierarchical relationships between them.