arXiv:2605.27459v1 Announce Type: new
Abstract: Simulation of post-prandial pharmacokinetics, such as muscle protein synthesis (MPS) through mTORC1 and insulin-induced glucose uptake, is often challenging due to the computational intensity of the multi-compartmental approach. In this study, I introduce an in silico metabolic simulator that uses bi-compartmental Bateman kinetic processes, gamma-variate distributions, and finite state machine reasoning to solve temporal differential equations instantaneously, generating metabolic curves and predictions depending on input meals. The novel underlying algorithm was custom-built entirely independent of third-party libraries or external services. This original computational engine, bridging the gap between academia and the digital health sector, is integrated within a web dashboard and provided as a service via REST APIs. The average response time is approximately 135 ms with a maximum below 750 ms. The multi-dimensional model was calibrated using a Landmark Validation approach across diverse dietary conditions (Whey Protein, mixed meal, OGTT) and optimized via Grid Search. Ultimately, the system achieved a global physiologically optimal Mean Absolute Percentage Error (MAPE) of $sim18%$ while maintaining an algorithmic complexity of $O(n log n)$.
Crisis support teams’ technological openness and learning attitudes toward the AI based virtual patient system crisis support VR
BackgroundAgainst the backdrop of escalating global humanitarian crises, innovative didactic simulations are becoming increasingly important. A promising alternative to traditional classroom-based didactics for learning psychological