arXiv:2606.07562v1 Announce Type: new
Abstract: RNA design consists of discovering a nucleotide sequence that optimizes predefined criteria, such as secondary structure. It is useful for synthetic biology, medicine, and nanotechnology. We propose Montparnasse, a Monte Carlo search framework based on Generalized Nested Rollout Policy Adaptation, augmented with a problem-specific prior, slow and long adaptation at level 1, and a lexicographic multicriteria evaluation. Montparnasse solves all 100 puzzles of the Eterna100 V1 benchmark consistently faster than DesiRNA, the previous state of the art, across all time limits, reaching full coverage more than three times faster overall. On messenger RNA secondary structure optimization for hemoglobin alpha, it identifies sequences with more paired bases than the MFE-optimal solution of LinearDesign.
Kalmer, a specific based-App intervention for the treatment of Non-suicidal self-injury (NSSI): a technical and usability study in a non-clinical population
IntroductionNon-suicidal self-injury (NSSI), defined as the deliberate infliction of harm to oneself without suicidal intent, poses a significant and growing mental health concern worldwide, particularly