The Hidden Power of Normalization: Exponential Capacity Control in Deep Neural Networks

arXiv:2511.00958v1 Announce Type: cross Abstract: Normalization methods are fundamental components of modern deep neural networks (DNNs). Empirically, they are known to stabilize optimization dynamics and

FeNN-DMA: A RISC-V SoC for SNN acceleration

arXiv:2511.00732v1 Announce Type: cross Abstract: Spiking Neural Networks (SNNs) are a promising, energy-efficient alternative to standard Artificial Neural Networks (ANNs) and are particularly well-suited to

Parameter Interpolation Adversarial Training for Robust Image Classification

arXiv:2511.00836v1 Announce Type: cross Abstract: Though deep neural networks exhibit superior performance on various tasks, they are still plagued by adversarial examples. Adversarial training has

Region-Aware Reconstruction Strategy for Pre-training fMRI Foundation Model

arXiv:2511.00443v1 Announce Type: cross Abstract: The emergence of foundation models in neuroimaging is driven by the increasing availability of large-scale and heterogeneous brain imaging datasets.

FlashEVA: Accelerating LLM inference via Efficient Attention

arXiv:2511.00576v1 Announce Type: cross Abstract: Transformer models have revolutionized natural language processing, achieving state-of-the-art performance and demonstrating remarkable scalability. However, their memory demands, particularly due

Integrated Multi-omics Reveals MEF2C as a Direct Regulator of Microglial Immune and Synaptic Programs

October 31, 2025

arXiv:2510.25780v1 Announce Type: new
Abstract: Background: Patients carrying MEF2C haploinsufficiency develop a recognizable neurodevelopmental syndrome featuring intellectual disability, treatment-resistant seizures, and autism spectrum behaviors. While MEF2C’s critical roles in cardiac development and neuronal function are well-established, its specific transcriptional operations within microglia (the brain’s resident immune cells) have remained surprisingly undefined. This knowledge gap is particularly notable given that MEF2C syndrome patients consistently present with neurological symptoms while cardiac abnormalities are rarely observed.
Results: We used human iPSC-derived microglia with MEF2C knockout to perform integrated ChIP-seq and RNA-seq analyses. Our data demonstrate that MEF2C directly binds 1,258 genomic loci and regulates 755 differentially expressed genes (FDR < 0.05). Integration identified 69 high-confidence direct targets with statistically significant overlap (p = 8.87 x 10^-5). The most dramatic changes included ADAMDEC1, a microglia-enriched metalloprotease for extracellular matrix remodeling (log2FC = -4.76, adj. p = 3.30 x 10^-19), and CARD11, an NF-kappaB signaling component (log2FC = -5.16, adj. p = 5.95 x 10^-5). Pathway analysis revealed profound disruption of Fc-gamma receptor signaling (p = 3.11 x 10^-7), alongside widespread changes in immune response and synaptic organization pathways.
Conclusion: These findings establish MEF2C as a master transcriptional regulator coordinating both immune effector functions and synaptic interaction programs in microglia. The observed changes, particularly in Fc receptor signaling critical for synaptic pruning, likely underlie the neurological manifestations of MEF2C syndrome.
Keywords: MEF2C, microglia, ChIP-seq, RNA-seq, neurodevelopmental disorders

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