arXiv:2604.06405v1 Announce Type: new
Abstract: Data harmonization remains a major bottleneck for integrative analysis due to heterogeneity in schemas, value representations, and domain-specific conventions. BDI-Kit provides an extensible toolkit for schema and value matching. It exposes two complementary interfaces tailored to different user needs: a Python API enabling developers to construct harmonization pipelines programmatically, and an AI-assisted chat interface allowing domain experts to harmonize data through natural language dialogue. This demonstration showcases how users interact with BDI-Kit to iteratively explore, validate, and refine schema and value matches through a combination of automated matching, AI-assisted reasoning, and user-driven refinement. We present two scenarios: (i) using the Python API to programmatically compose primitives, examine intermediate outputs, and reuse transformations; and (ii) conversing with the AI assistant in natural language to access BDI-Kit’s capabilities and iteratively refine outputs based on the assistant’s suggestions.
The Central Coupler of the AAA+ ATPase ClpXP Controls Intersubunit Communication and Couples the Conversion of Chemical Energy into the Generation of Force
ClpX is a clockwise hexameric helical arrangement that hydrolyzes ATP to unfold proteins and translocate them into the proteolytic chamber. We investigate the central coupler,