arXiv:2604.07502v1 Announce Type: cross
Abstract: For six decades, software engineering principles have been optimized for a single consumer: the human developer. The rise of agentic AI development, where LLM-based agents autonomously read, write, navigate, and debug codebases, introduces a new primary consumer with fundamentally different constraints. This paper presents a systematic analysis of human-centric conventions under agentic pressure and proposes a key design principle: semantic density optimization, eliminating tokens that carry zero information while preserving tokens that carry high semantic value. We validate this principle through a controlled experiment on log format token economy across four conditions (human-readable, structured, compressed, and tool-assisted compressed), demonstrating a counterintuitive finding: aggressive compression increased total session cost by 67% despite reducing input tokens by 17%, because it shifted interpretive burden to the model’s reasoning phase. We extend this principle to propose the rehabilitation of classical anti-patterns, introduce the program skeleton concept for agentic code navigation, and argue for a fundamental decoupling of semantic intent from human-readable representation.
Dysregulation of Hippo Signaling Pathway as a Convergent Mechanism Underlying Choroid Plexus Defects in Bipolar Disorder
Bipolar disorder (BD) is a prevalent and highly heritable psychiatric condition. Developmental mechanisms are implicated but the specific molecular origins remain unclear. The choroid plexus

