arXiv:2511.04332v1 Announce Type: cross
Abstract: Differentially private in-context learning (DP-ICL) has recently become an active research topic due to the inherent privacy risks of in-context learning. However, existing approaches overlook a critical component of modern large language model (LLM) pipelines: the similarity search used to retrieve relevant context data. In this work, we introduce a DP framework for in-context learning that integrates nearest neighbor search of relevant examples in a privacy-aware manner. Our method outperforms existing baselines by a substantial margin across all evaluated benchmarks, achieving more favorable privacy-utility trade-offs. To achieve this, we employ nearest neighbor retrieval from a database of context data, combined with a privacy filter that tracks the cumulative privacy cost of selected samples to ensure adherence to a central differential privacy budget. Experimental results on text classification and document question answering show a clear advantage of the proposed method over existing baselines.
OptoLoop: An optogenetic tool to probe the functional role of genome organization
The genome folds inside the cell nucleus into hierarchical architectural features, such as chromatin loops and domains. If and how this genome organization influences the

