Evidence for a protein leverage effect on food intake but not on body mass index in a Norwegian population

Objective In this pre-registered study, we aimed to explore the protein leverage hypothesis in a general population, by studying the relationship between habitual dietary protein intake, total energy intake, and body mass index (BMI), and whether proportion of ultra-processed food (UPF) was associated with any of these variables. Methods We used regression-based analyses to investigate these phenomena in cross-sectional data from a Norwegian population-based study, the seventh survey of Tromsoe Study 2015-2016, (n = 11,152; 40-99 years). Results Total energy intake was negatively associated with proportion of dietary protein (L = -0.36, p < .001) and positively associated with dietary fat (L = 0.33, p < .001). The relationship between BMI and dietary protein was positive but small (b = 0.01, p < .001). Proportion of UPFs was positively associated with total energy intake (b = 554, p < .001), negatively associated with proportion of dietary protein (b = -2.0, p < .001), and positively associated with BMI (b = 0.011, p = .026). Conclusions In summary, our study of middle-to-older aged Norwegians provides strong support for a protein leverage effect on energy intake but no evidence for an effect of protein leverage on BMI.

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