arXiv:2511.03993v1 Announce Type: cross
Abstract: Network anomaly detection systems encounter several challenges with traditional detectors trained offline. They become susceptible to concept drift and new threats such as zero-day or polymorphic attacks. To address this limitation, we propose a Ca$^2+$-modulated learning framework that draws inspiration from astrocytic Ca$^2+$ signaling in the brain, where rapid, context-sensitive adaptation enables robust information processing. Our approach couples a multicellular astrocyte dynamics simulator with a deep neural network (DNN). The simulator models astrocytic Ca$^2+$ dynamics through three key mechanisms: IP$_3$-mediated Ca$^2+$ release, SERCA pump uptake, and conductance-aware diffusion through gap junctions between cells. Evaluation of our proposed network on CTU-13 (Neris) network traffic data demonstrates the effectiveness of our biologically plausible approach. The Ca$^2+$-gated model outperforms a matched baseline DNN, achieving up to $sim$98% accuracy with reduced false positives and negatives across multiple train/test splits. Importantly, this improved performance comes with negligible runtime overhead once Ca$^2+$ trajectories are precomputed. While demonstrated here for cybersecurity applications, this Ca$^2+$-modulated learning framework offers a generic solution for streaming detection tasks that require rapid, biologically grounded adaptation to evolving data patterns.
OptoLoop: An optogenetic tool to probe the functional role of genome organization
The genome folds inside the cell nucleus into hierarchical architectural features, such as chromatin loops and domains. If and how this genome organization influences the