arXiv:2604.02988v1 Announce Type: cross
Abstract: Given a user’s complex information need, a multi-agent Deep Research system iteratively plans, retrieves, and synthesizes evidence across hundreds of documents to produce a high-quality answer. In one possible architecture, an orchestrator agent coordinates the process, while parallel worker agents execute tasks. Current Deep Research systems, however, often rely on hand-engineered prompts and static architectures, making improvement brittle, expensive, and time-consuming. We therefore explore various multi-agent optimization methods to show that enabling agents to self-play and explore different prompt combinations can produce high-quality Deep Research systems that match or outperform expert-crafted prompts.
Dissecting polycomb complexes for enhanced fetal hemoglobin production
Polycomb repressive complexes PRC1 and PRC2 regulate diverse developmental processes, including the fetal-to-adult switch in hemoglobin production, a process whose reversal is a goal for