Patient-reported outcomes have become standard in facial skin cancer surgery, yet clinicians currently lack validated tools to predict postoperative appearance satisfaction from preoperative patient characteristics. We developed and internally validated a prediction model for appearance satisfaction three months after facial skin cancer reconstruction. A prospective cohort study enrolled 287 patients at a tertiary referral center […]
Primary Care Obesity Management at the Threshold of the GLP-1 Era: A Survey-Based Change Readiness Assessment
Abstract Background Between 2021 and 2022, primary care obesity management was entering the early diffusion phase of newer anti obesity pharmacotherapy, as GLP1 based treatments began reshaping expectations. However, it was unclear whether primary care clinicians and practice environments were prepared to deliver comprehensive obesity care. (1,2) Methods In 2021 to 2022, we surveyed 276 […]
HHBayes: A Flexible Bayesian Framework for Simulating and Analyzing Household Transmission Dynamics
Household transmission studies are important for understanding infectious disease transmission and evaluating interventions; however, they are frequently constrained by methodological challenges, including in study design and sample size determination, and in estimating parameters of interest after collecting the data. Existing tools often lack flexibility in modeling age-specific susceptibility, infectivity patterns, and the impact of interventions […]
Automated Detection of Macro-Reentrant Atrial Tachycardia Circuits Using LAT-Derived Graph Networks
Background: Accurate identification of macro-reentrant atrial tachycardia (AT) circuits is critical for successful ablation but remains challenging with conventional mapping techniques. The aim of this study was to automatically detect macro-reentrant AT loops from high-density local activation time (LAT) maps. Methods: We developed an algorithm for automated detection of macro-reentrant AT circuits using LAT-derived directed […]
An AI-based mental health guardrail and dataset for identifying psychiatric crises in text-based conversations
npj Digital Medicine, Published online: 03 April 2026; doi:10.1038/s41746-026-02579-5 An AI-based mental health guardrail and dataset for identifying psychiatric crises in text-based conversations
Consistency of Serial CSF alpha-Synuclein Seed Amplification Assay Results in the Parkinson’s Progression Marker Initiative
Studies reporting alpha-synuclein seed amplification assay (aSyn-SAA) results are often cross-sectional. Here we investigated the intra-individual consistency of aSyn-SAA results over time from participants in the Parkinson’s Progression Marker Initiative (PPMI). A total of 1238 participants had >1 CSF aSyn-SAA result for analysis (Parkinson’s disease [PD]=633, prodromal =563, healthy control [HC]=42) which were collected over […]
Label-free pathological subtyping of non-small cell lung cancer using deep classification and virtual immunohistochemical staining
npj Digital Medicine, Published online: 03 April 2026; doi:10.1038/s41746-026-02557-x Label-free pathological subtyping of non-small cell lung cancer using deep classification and virtual immunohistochemical staining
User-preference alignment with uncertainty-aware interactive rectification for liver organ and tumor segmentation and analysis from CT images
npj Digital Medicine, Published online: 03 April 2026; doi:10.1038/s41746-026-02544-2 User-preference alignment with uncertainty-aware interactive rectification for liver organ and tumor segmentation and analysis from CT images
Sensor-based digital health technologies to capture endpoints in recent clinical trials: a scoping review
npj Digital Medicine, Published online: 03 April 2026; doi:10.1038/s41746-026-02512-w Sensor-based digital health technologies to capture endpoints in recent clinical trials: a scoping review
Patient characteristics associated with participation in cardiorespiratory exercise during stroke rehabilitation: a multisite observational cohort study
Objectives: Among individuals attending stroke rehabilitation, we aimed to determine the proportion who participated in cardiorespiratory exercise, identify patient characteristics predicting participation, and describe exercise characteristics. Design, setting, and participants: This was an observational cohort study involving all patients admitted to four stroke rehabilitation centres in Ontario, Canada, during March or October 2019, or over […]
IgG antibody responses against antigenic salivary peptides from subgenus Nyssorhynchus and Anopheles vectors in GrandAnse, Haiti
Anopheles albimanus (Nyssorhynchus) is featured as the main malaria vector on Hispaniola. However, five other Anopheles species have been reported circulating in the area; four of them belonging to the subgenus Anopheles (An. crucians, An. grabhamii, An. pseudopunctipennis, and An. vestitipennis) and another one to the Nyssorhynchus subgenus (An. argyritarsis). Previous studies on mosquitoes in […]
Carsickness Therapy Based on Brain-Computer Interface Enhanced Mindfulness Meditation Training
Carsickness impairs comfort and affects a large proportion of the population. However, interventions that provide a therapeutic solution to carsickness have yet to be established. Here we introduce a wearable mindfulness meditation brain-computer interface (MM-BCI) system as a closed-loop training therapy for carsickness. The system records electroencephalographic activity, decodes meditative state in real time and […]