Household transmission studies are important for understanding infectious disease transmission and evaluating interventions; however, they are frequently constrained by methodological challenges, including in study design and sample size determination, and in estimating parameters of interest after collecting the data. Existing tools often lack flexibility in modeling age-specific susceptibility, infectivity patterns, and the impact of interventions […]
Automated Detection of Macro-Reentrant Atrial Tachycardia Circuits Using LAT-Derived Graph Networks
Background: Accurate identification of macro-reentrant atrial tachycardia (AT) circuits is critical for successful ablation but remains challenging with conventional mapping techniques. The aim of this study was to automatically detect macro-reentrant AT loops from high-density local activation time (LAT) maps. Methods: We developed an algorithm for automated detection of macro-reentrant AT circuits using LAT-derived directed […]
An AI-based mental health guardrail and dataset for identifying psychiatric crises in text-based conversations
npj Digital Medicine, Published online: 03 April 2026; doi:10.1038/s41746-026-02579-5 An AI-based mental health guardrail and dataset for identifying psychiatric crises in text-based conversations
Consistency of Serial CSF alpha-Synuclein Seed Amplification Assay Results in the Parkinson’s Progression Marker Initiative
Studies reporting alpha-synuclein seed amplification assay (aSyn-SAA) results are often cross-sectional. Here we investigated the intra-individual consistency of aSyn-SAA results over time from participants in the Parkinson’s Progression Marker Initiative (PPMI). A total of 1238 participants had >1 CSF aSyn-SAA result for analysis (Parkinson’s disease [PD]=633, prodromal =563, healthy control [HC]=42) which were collected over […]
Label-free pathological subtyping of non-small cell lung cancer using deep classification and virtual immunohistochemical staining
npj Digital Medicine, Published online: 03 April 2026; doi:10.1038/s41746-026-02557-x Label-free pathological subtyping of non-small cell lung cancer using deep classification and virtual immunohistochemical staining
User-preference alignment with uncertainty-aware interactive rectification for liver organ and tumor segmentation and analysis from CT images
npj Digital Medicine, Published online: 03 April 2026; doi:10.1038/s41746-026-02544-2 User-preference alignment with uncertainty-aware interactive rectification for liver organ and tumor segmentation and analysis from CT images
Sensor-based digital health technologies to capture endpoints in recent clinical trials: a scoping review
npj Digital Medicine, Published online: 03 April 2026; doi:10.1038/s41746-026-02512-w Sensor-based digital health technologies to capture endpoints in recent clinical trials: a scoping review
Patient characteristics associated with participation in cardiorespiratory exercise during stroke rehabilitation: a multisite observational cohort study
Objectives: Among individuals attending stroke rehabilitation, we aimed to determine the proportion who participated in cardiorespiratory exercise, identify patient characteristics predicting participation, and describe exercise characteristics. Design, setting, and participants: This was an observational cohort study involving all patients admitted to four stroke rehabilitation centres in Ontario, Canada, during March or October 2019, or over […]
IgG antibody responses against antigenic salivary peptides from subgenus Nyssorhynchus and Anopheles vectors in GrandAnse, Haiti
Anopheles albimanus (Nyssorhynchus) is featured as the main malaria vector on Hispaniola. However, five other Anopheles species have been reported circulating in the area; four of them belonging to the subgenus Anopheles (An. crucians, An. grabhamii, An. pseudopunctipennis, and An. vestitipennis) and another one to the Nyssorhynchus subgenus (An. argyritarsis). Previous studies on mosquitoes in […]
Carsickness Therapy Based on Brain-Computer Interface Enhanced Mindfulness Meditation Training
Carsickness impairs comfort and affects a large proportion of the population. However, interventions that provide a therapeutic solution to carsickness have yet to be established. Here we introduce a wearable mindfulness meditation brain-computer interface (MM-BCI) system as a closed-loop training therapy for carsickness. The system records electroencephalographic activity, decodes meditative state in real time and […]
UPDATE trial Stage 2: a pre-post exploratory analysis of a behavioural support intervention to reduce ultra-processed food intake, increase minimally processed food intake, and increase physical activity in adults living with overweight or obesity
Introduction High consumption of ultra-processed foods (UPF) is associated with adverse health outcomes and weight gain. Despite increasing calls for behavioural strategies to reduce UPF intake, no theory-informed intervention targeting UPF reduction has been evaluated in UK adults in alignment with national dietary guidance. We assessed the feasibility, acceptability, and preliminary behavioural and clinical outcomes […]
Antimicrobial resistance in WHO priority bacteria from a One Health perspective in Cameroon: a systematic review and meta-analysis
Antimicrobial resistance (AMR) is classified by the World Health Organization (WHO) as one of humanity’s ten global public health threats. This review aimed to estimate the prevalence, temporal trends and regional distribution of AMR in WHO priority bacteria across human, animal and environmental sources in Cameroon. This review was conducted following PRISMA 2020 guidelines, with […]