arXiv:2604.04941v1 Announce Type: new
Abstract: Many combinatorial optimisation problems hide algebraic structures that, once exposed, shrink the search space and improve the chance of finding the global optimal solution. We present a general framework that (i) identifies algebraic structure, (ii) formalises operations, (iii) constructs quotient spaces that collapse redundant representations, and (iv) optimises directly over these reduced spaces. Across a broad family of rule-combination tasks (e.g., patient subgroup discovery and rule-based molecular screening), conjunctive rules form a monoid. Via a characteristic-vector encoding, we prove an isomorphism to the Boolean hypercube $,1^n$ with bitwise OR, so logical AND in rules becomes bitwise OR in the encoding. This yields a principled quotient-space formulation that groups functionally equivalent rules and guides structure-aware search. On real clinical data and synthetic benchmarks, quotient-space-aware genetic algorithms recover the global optimum in 48% to 77% of runs versus 35% to 37% for standard approaches, while maintaining diversity across equivalence classes. These results show that exposing and exploiting algebraic structure offers a simple, general route to more efficient combinatorial optimisation.
Bioethical considerations in deploying mobile mental health apps in LMIC settings: insights from the MITHRA pilot study in rural India
IntroductionIn India, untreated depression among women contributes significantly to morbidity and mortality, underscoring an urgent need for accessible and ethically grounded mental health interventions. Mobile



