Magnetoencephalography reveals adaptive neural reorganization maintaining lexical-semantic proficiency in healthy aging

Although semantic cognition remains behaviorally stable with age, neuroimaging studies report age-related alterations in response to semantic context. We aimed to reconcile these inconsistent findings

Excitatory nicotinic signaling drives action potential bursting in dopaminergic axons

Axons of dopamine (DA) neurons express nicotinic receptors (nAChRs) that have been shown to both facilitate and suppress striatal DA release, but the mechanisms underlying

Why motor learning involves multiple systems: an algorithmic perspective

The initial stage of learning motor skills involves exploring vast action spaces, making it impractical to learn the value of every possible action independently. This

Dual cholinergic mechanisms for sculpting striatal dopamine in vivo

Striatal dopamine (DA) and acetylcholine constitute a computationally powerful neuromodulatory dyad that orchestrates action selection, motivational vigor, and reward learning. Striatal cholinergic interneurons (CINs) synapse

Real-Time Segmentation and Classification of Birdsong Syllables for Learning Experiments

Songbirds are essential animal models for studying neuronal and behavioral mechanisms of learned vocalizations. Bengalese finch (Lonchura striata domestica) songs contain a limited number of

Cardiac Biomarkers to Refine Pre-Test Probability for Coronary Obstruction and Predict Survival after Revascularisation in Chronic Coronary Syndrome

December 20, 2025

Background and aims The utility of cardiovascular and inflammatory biomarkers to detect coronary obstruction and predict survival benefit of revascularisation in chronic coronary syndrome (CCS) remains unclear. Methods Patients undergoing coronary angiography for suspected CCS were studied. High-sensitivity cardiac troponin T (hsTnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and copeptin were measured. Diagnostic performance to detect anatomical coronary stenosis (i.e. [≥]50%) was assessed using Receiver Operating Characteristic (ROC) analysis with Net Reclassification Improvement (NRI). Survival analysis using multivariate Cox regression assessed treatment-stratified biomarker performance and biomarker x treatment interaction. Results Among 2,251 patients, 888 (39.4%) had coronary obstruction. Only hsTnT provided meaningful diagnostic capacity (Area Under the Curve; AUC 0.669), comparable with risk factor-weighted clinical likelihood (RF-CL) estimate recommended by the current guidelines (AUC 0.663). Reclassification value demonstrated an inverse relationship to RF-CL: very low (NRI=38.4%), low (NRI=19.3%), and intermediate/high likelihood (NRI=12.4%). NT-proBNP was the strongest universal mortality predictor across all treatment categories: Optimal Medical Therapy (OMT; HR 1.488, 95%CI:1.288-1.720, p<0.001), Percutaneous Coronary Intervention (PCI; HR 1.220, 95%CI:1.020-1.458, p=0.029), Coronary Artery Bypass Grafting (CABG; HR 1.220, 95%CI:1.049-1.420, p=0.010). Interaction analysis (p=0.024) demonstrated that in patients with NT-proBNP <150 pg/mL the revascularisation group has an improved survival (HR 0.64, 95%CI:0.47-0.87, p=0.005), whilst this was not observed for the patients with NT-proBNP ?150 pg/mL (HR 0.96, 95%CI:0.71-1.30, p=0.782). Conclusions HsTnT provides meaningful diagnostic value with RF-CL category-specific incremental benefit following an inverse gradient pattern. The NT-proBNP 150 pg/mL threshold identifies patients with improved survival after revascularisation.

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