The integration of social media into human subjects research offers significant opportunities for data collection, disease surveillance, and participant recruitment. However, it also poses a number of ethical challenges. This article evaluates the dual nature of social media as a research tool, highlighting its potential benefits while also addressing concerns about exacerbating health disparities, compromising participant privacy and confidentiality, and perpetuating discriminatory practices. By exploring issues related to equity and privacy, this article discusses the implications of digital recruitment and online behavioral advertising, underscoring the vital role of Institutional Review Boards (IRBs) in ensuring ethical standards are upheld. Furthermore, this work proposes key strategies for researchers and regulatory authorities, emphasizing community engagement and inclusive recruitment practices. The analysis aims to guide stakeholders in navigating the ethical complexities of digital research, fostering transparency, trust, and accountability in the realm of human subjects research.
