Exact Synthetic Populations for Scalable Societal and Market Modeling

Accelerometer-Derived Rest-Activity Rhythm Amplitude, Genetic Predisposition, and the Risk of Ischemic Heart Disease: Observational and Mendelian Randomization Study

Background: The rest-activity rhythm amplitude (RARA), as a fundamental human behavior, has been linked to various health conditions. However, its causal relationship with ischemic heart

Multimodal Data–Driven Explainable Prognostic Model for Major Adverse Cardiovascular Events Prediction in Patients With Unstable Angina and Heart Failure With Preserved Ejection Fraction: Multicenter, Cross-Regional Cohort Study

Background: Heart failure with preserved ejection fraction (HFpEF) and unstable angina (UA) often coexist in clinical practice, constituting a high-risk cardiovascular phenotype with a markedly

Mobile Phone Messaging–Based Interventions to Improve Physical Activity in Patients With Cancer: Systematic Review and Meta-Analysis

Background: Despite the benefits of physical activity for improving cancer-related outcomes, the majority of patients with cancer fail to meet physical activity guidelines. Mobile phone

Development and Validation of a Revised Multidimensional Digital Health Literacy Scale: Secondary Analysis Using Cross-Sectional Data From the 2022 GetCheckedOnline Community Survey In British Columbia, Canada

Background: Digital technologies are reshaping health care, making digital health literacy (DHL) a critical competency for navigating online health information. Although widely conceived and measured

Cost-Utility Analysis and Value-Based Pricing of Digital Therapeutics for Pulmonary Rehabilitation in Chronic Respiratory Disease: Economic Evaluation Based on a Randomized Controlled Trial

Background: Pulmonary rehabilitation, a nonpharmacological treatment for chronic respiratory diseases, is underused due to limited access and time constraints. In a randomized controlled trial, the