Performance Assessment Strategies for Language Model Applications in Healthcare

arXiv:2509.08087v2 Announce Type: replace-cross
Abstract: Language models (LMs) represent an emerging paradigm within artificial intelligence, with applications throughout the medical enterprise. A comprehensive understanding of the clinical task and awareness of the variability in performance when implemented in actual clinical environments lays the foundation for the LM application assessment. Presently, a prevalent method for evaluating the performance of these generative models relies on quantitative benchmarks. Such benchmarks have limitations and may suffer from train-to-the-test overfitting, optimizing performance for a specified test set at the cost of generalizability across other tasks and data distributions. Evaluation strategies leveraging human expertise and utilizing cost-effective computational models as evaluators are gaining interest. We discuss current state-of-the-art methodologies for assessing the performance of LM applications in healthcare and medical devices.